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Thromb Res. 2015 Feb;135 Suppl 1:S12-5. doi: 10.1016/S0049-3848(15)50433-7. Epub 2015 Feb 9.

Gender differences in cancer patients with acute venous thromboembolism.

Collaborators (146)

Monreal M, Decousus H, Prandoni P, Brenner B, Barba R, Di Micco P, Bertoletti L, Schellong S, Papadakis M, Tzoran I, Reis A, Bosevski M, Bounameaux H, Malý R, Adarraga MD, Alvarado AV, Arcelus JI, Barba M, Barrón M, Barrón-Andrés B, Bascuñana J, Benítez JF, Blanco-Molina A, Casado I, Conget F, Chaves EL, de Ancos C, del Molino F, del Toro J, Falgá C, Farfán AI, Fernández-Capitán C, Font L, Gallego P, García-Bragado F, Gómez V, González J, González-Marcano D, Grau E, Guijarro R, Gutiérrez J, Hernández L, Hernández-Huerta S, Jara-Palomares L, Jaras MJ, Jiménez D, Lecumberri R, Lobo JL, López-Jiménez L, López-Montes L, López-Reyes R, López-Sáez JB, Lorente MA, Lorenzo M, Luque JM, Madridano O, Marchena PJ, Martín-Antorán JM, Mellado M, Monreal M, Morales MV, Nauffal D, Nieto JA, Núñez MJ, Otero R, Pagán B, Pedrajas JM, Peris ML, Pons I, Porras JA, Puerta P, Riera-Mestre A, Rivas A, Rodríguez-Dávila MA, Román P, Rosa V, Ruiz-Giménez N, Ruiz J, Samperiz A, Sánchez R, Soler S, Soto MJ, Suriñach JM, Tiberio G, Tilvan RM, Tirado R, Trujillo-Santos J, Uresandi F, Valero B, Valle R, Vela J, Villalobos A, Malfante P, Matías V, Vivero F, Verhamme P, Peerlinck K, Wells P, Malý R, Hirmerova J, Salgado E, Bertoletti L, Bura-Riviere A, Moustafa F, Farge-Bancel D, Hij A, Mahe I, Merah A, Quere I, Schellong S, Babalis D, Papadakis M, Tzinieris I, Braester A, Brenner B, Tzoran I, Zeltser D, Amitrano M, Apollonio A, Barillari G, Cannavaccioulo F, Ciammaichella M, Dentali F, Di Micco P, Enea I, Guida A, Maida R, Pace F, Pasca S, Pesavento R, Piovella C, Prandoni P, Rota L, Tiraferri E, Tufano A, Visonà A, Mesquita P, Ribeiro de Almeida JL, Sousa MS, Bosevski M, Zdraveska M, Alatri A, Bounameaux H, Calanca L, Mazzolai L, Serrano JC.

Author information

1
Department of Internal Medicine, Hospital General Universitario Santa Lucía, Murcia, Spain.
2
Department of Pneumonology, Complejo Hospitalario San Pedro, La Rioja, Spain.
3
Department of Internal Medicine, Hospital Universitario Miguel Servet, Zaragoza, Spain.
4
Department of Internal Medicine, Parc Sanitari Sant Joan de Deu-Hospital General, Barcelona, Spain.
5
Department of Haematology, Western Galilee Hospital, Nahariya, Israel.
6
Internal Medicine and Vascular Diseases Unit, Hôpital Saint-Louis, Paris, France.
7
Department of Pneumonology, Hospital General Universitario de Alicante, Alicante, Spain.
8
Department of Cardiovascular Science, Vascular Medicine and Haemostasis, University of Leuven, Leuven, Beigium.
9
Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. Electronic address: mmonreal.germanstrias@gencat.cat.

Abstract

BACKGROUND:

The outcome of cancer patients with acute venous thromboembolism (VTE) may differ according to gender.

METHODS:

We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender.

RESULTS:

As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08).

CONCLUSIONS:

During the course of anticoagulation, cancer women with VTE had a better outcome than men.

KEYWORDS:

Anticoagulant drugs; Cancer; Gender; Hemorrhage; Mortality; Recurrence; Venous thromboembolism

PMID:
25903526
DOI:
10.1016/S0049-3848(15)50433-7
[Indexed for MEDLINE]
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