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Contact Dermatitis. 2015 Dec;73(6):350-7. doi: 10.1111/cod.12401. Epub 2015 Apr 23.

Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test® (Mekos test) sensitizing the tested patients?

Author information

1
Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, 901 85, Umeå, Sweden.
2
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 214 28 Malmö, Sweden.

Abstract

BACKGROUND:

In a population study using TRUE Test®, we noted late reactions to p-tert-butylphenol-formaldehyde resin (PTBP-FR) in 0.5% of subjects tested.

OBJECTIVES:

In order to explore possible test sensitization, differences in the contents of sensitizers within PTBP-FR in test preparations for TRUE Test® and Finn Chambers® were analysed. Subjects allergic to PTBP-FR and subjects with late reactions to PTBP-FR were retested in order to explore whether these groups reacted to different PTBP-FR sensitizers.

PATIENTS/MATERIALS/METHODS:

Four individuals with late reactions and 5 subjects with established allergy to PTBP-FR were retested with defined PTBP-FR sensitizers. PTBP-FR constituents in patches from TRUE Test® were analysed with high-performance liquid chromatography. Previously analysed samples of PTBP-FR constituents served as a reference.

RESULTS:

The pattern of reaction to PTBP-FR sensitizers was similar in both groups. Subjects with suspected sensitization had somewhat stronger reactions than controls. The concentrations of monomers, dimers and trimers were generally higher in the TRUE Test® resin than in reference substances.

CONCLUSIONS:

Retesting did not add information regarding causes of possible sensitization. Analysis showed that the resin used in TRUE Test® has a lower degree of polymerization or condensation, which may enhance its sensitizing properties. A follow-up of late reactions to PTBP-FR in TRUE Test® should be carried out.

KEYWORDS:

active sensitization; late reactions; retesting

Comment in

PMID:
25903478
DOI:
10.1111/cod.12401
[Indexed for MEDLINE]

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