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Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2281-9. doi: 10.1073/pnas.1504407112. Epub 2015 Apr 22.

Inferring epigenetic dynamics from kin correlations.

Author information

1
Kavli Institute for Theoretical Physics and.
2
Laboratoire de Physique Statistique, UMR8550, Ecole Normale Supérieure, 75005 Paris, France; Institut de Biologie, UMR 8197, Ecole Normale Supérieure, 75230 Paris, France; and Université Paris Diderot, 75205 Paris, France.
3
Kavli Institute for Theoretical Physics and Department of Physics, University of California, Santa Barbara, CA 93106; shraiman@kitp.ucsb.edu.

Abstract

Populations of isogenic embryonic stem cells or clonal bacteria often exhibit extensive phenotypic heterogeneity that arises from intrinsic stochastic dynamics of cells. The phenotypic state of a cell can be transmitted epigenetically in cell division, leading to correlations in the states of cells related by descent. The extent of these correlations is determined by the rates of transitions between the phenotypic states. Therefore, a snapshot of the phenotypes of a collection of cells with known genealogical structure contains information on phenotypic dynamics. Here, we use a model of phenotypic dynamics on a genealogical tree to define an inference method that allows extraction of an approximate probabilistic description of the dynamics from observed phenotype correlations as a function of the degree of kinship. The approach is tested and validated on the example of Pyoverdine dynamics in Pseudomonas aeruginosa colonies. Interestingly, we find that correlations among pairs and triples of distant relatives have a simple but nontrivial structure indicating that observed phenotypic dynamics on the genealogical tree is approximately conformal--a symmetry characteristic of critical behavior in physical systems. The proposed inference method is sufficiently general to be applied in any system where lineage information is available.

KEYWORDS:

Bethe lattice; conformal symmetry; correlation functions; stochastic dynamics

PMID:
25902540
PMCID:
PMC4426465
DOI:
10.1073/pnas.1504407112
[Indexed for MEDLINE]
Free PMC Article

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