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Immunity. 2015 Apr 21;42(4):607-12. doi: 10.1016/j.immuni.2015.04.005.

Regulatory B cells: origin, phenotype, and function.

Author information

1
Centre for Rheumatology Research, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK.
2
Centre for Rheumatology Research, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, UK. Electronic address: c.mauri@ucl.ac.uk.

Abstract

Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. Recent work has shown that different inflammatory environments induce distinct Breg cell populations. Although these findings highlight the relevance of inflammatory signals in the differentiation of Breg cells, they also raise other questions about Breg cell biology and phenotype. For example, what are the functional properties and phenotype of Breg cells? Can a Breg cell arise at every stage in B cell development? Is inflammation the primary requisite for Breg cell differentiation? Here, we use these questions to discuss the advances in understanding Breg cell biology, with a particular emphasis on their ontogeny; we propose that multiple Breg cell subsets can be induced in response to inflammation at different stages in development.

PMID:
25902480
DOI:
10.1016/j.immuni.2015.04.005
[Indexed for MEDLINE]
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