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J Matern Fetal Neonatal Med. 2016;29(7):1025-9. doi: 10.3109/14767058.2015.1034101. Epub 2015 Apr 22.

Weight gain in gestational diabetes: the effect of treatment modality.

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1
a Department of Obstetrics and Gynecology , St. Luke's-Roosevelt Hospital Center , New York , NY , USA.

Abstract

OBJECTIVE:

To evaluate treatment effectiveness (diet alone, insulin or glyburide) on maternal weight gain in gestational diabetes (GDM).

METHODS:

GDM patients were treated with diet alone, insulin or glyburide. Weight gain was stratified into: prior to GDM diagnosis, from diagnosis to delivery and total pregnancy weight gain. Good glycemic control was defined as mean blood glucose ≤ 105 mg/dl and obesity as Body Mass Index (BMI) ≥ 30 kg/m(2), overweight BMI 25-29 kg/m(2) and normal < 25 kg/m(2).

RESULTS:

Total weight gain was similar in all the treatment groups. Two-thirds of weight gain occurred prior to diagnosis (diet 85%, insulin 67% and glyburide 78%). Post-diagnosis, patients on diet alone gained less weight than those on insulin or glyburide (p < 0.001); insulin-treated patients showed greater weight gain than glyburide-treated patients (p < 0.001). Patients on diet with good glycemic control showed less weight gain after diagnosis than patients on insulin or glyburide (2.8 ± 13, 6.6 ± 10, 5.2 ± 7.9 lbs, respectively, p < 0.02). Poorly-controlled patients, regardless of treatment, had similar patterns of weight gain throughout pregnancy.

CONCLUSION:

Patterns of maternal weight gain in GDM pregnancies are associated with treatment modality and level of glycemic control.

KEYWORDS:

GDM; glyburide; glycemic control; insulin; weight gain in pregnancy

PMID:
25902398
DOI:
10.3109/14767058.2015.1034101
[Indexed for MEDLINE]
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