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Head Neck. 2016 Apr;38 Suppl 1:E741-6. doi: 10.1002/hed.24086. Epub 2015 Jul 30.

Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis.

Author information

1
Department of Oral and Maxillofacial Surgery, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
2
Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
3
The Sackler Faculty of Medicine, and The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
4
Cancer Research Center, The Chaim Sheba Medical Center, Tel-Hashomer, Israel.
5
Institute of Pathology, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel.

Abstract

BACKGROUND:

Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP.

METHODS:

Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8.

RESULTS:

Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found.

CONCLUSION:

High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up. © 2015 Wiley Periodicals, Inc. Head Neck 38: E741-E746, 2016.

KEYWORDS:

aneuploidy; chromosomal instability; oral cancer; oral lichen planus

PMID:
25900614
DOI:
10.1002/hed.24086
[Indexed for MEDLINE]

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