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Psychophysiology. 2015 Aug;52(8):1071-9. doi: 10.1111/psyp.12430. Epub 2015 Apr 20.

Chronic stress, inflammation, and glucose regulation in U.S. Hispanics from the HCHS/SOL Sociocultural Ancillary Study.

Author information

1
SDSU/UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California, USA.
2
Department of Psychiatry, University of California, San Diego, San Diego, California, USA.
3
Department of Psychology, San Diego State University, San Diego, California, USA.
4
Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
5
SDSU/UCSD Joint Doctoral Program in Global Health, San Diego, California, USA.
6
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA.
7
Collaborative Studies Coordinating Center, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
8
Department of Psychology, University of Miami, Coral Gables, Florida, USA.
9
Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Abstract

Diabetes prevalence is rising rapidly, and diabetes disproportionately affects Hispanics and other underserved groups. Chronic stress may contribute to diabetes risk, but few studies have examined this relationship in U.S. Hispanics. We examined associations of chronic stress with fasting glucose, glucose tolerance, and glycosylated hemoglobin (HbA1c) in Hispanics without diabetes, and also assessed indirect effects of stress through inflammation (CRP). Participants were 3,923 men and women, aged 18-74, without diabetes, from the four U.S. field centers (Bronx, NY; Chicago, IL; Miami, FL; San Diego, CA) of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) Sociocultural Ancillary study. Participants completed a measure of chronic life stress and a physical exam with oral glucose tolerance test. In a multivariate regression analysis with adjustment for demographic and health covariates, higher chronic stress was related to higher fasting glucose (standardized regression coefficient: β = .09, p < .01), postload glucose (β = .07, p < .05), and HbA1c levels (β = .08, p < .01). However, there was no indirect effect of stress through inflammation. Findings suggest that higher chronic stress is associated with poorer glucose regulation in Hispanics, prior to the onset of a clinical diabetes diagnosis.

KEYWORDS:

Glucose; Hispanic; Inflammation; Insulin; Stress

PMID:
25898909
PMCID:
PMC4640890
DOI:
10.1111/psyp.12430
[Indexed for MEDLINE]
Free PMC Article

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