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PLoS One. 2015 Apr 21;10(4):e0124503. doi: 10.1371/journal.pone.0124503. eCollection 2015.

Alternative splicing of SMPD1 in human sepsis.

Author information

1
Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Genome Analysis, Leibniz Institute for Age Research-Fritz Lipmann Institute, Jena, Germany.
2
Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany.
3
Department of Anesthesiology and Intensive Care Therapy, Jena University Hospital, Jena, Germany.
4
Hans Knöll Institute for Natural Product Research and Infection Biology, Leibniz Institute, Jena, Germany.
5
Genome Analysis, Leibniz Institute for Age Research-Fritz Lipmann Institute, Jena, Germany.
6
Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Department of Anesthesiology and Intensive Care Therapy, Jena University Hospital, Jena, Germany.

Abstract

Acid sphingomyelinase (ASM or sphingomyelin phosphodiesterase, SMPD) activity engages a critical role for regulation of immune response and development of organ failure in critically ill patients. Beside genetic variation in the human gene encoding ASM (SMPD1), alternative splicing of the mRNA is involved in regulation of enzymatic activity. Here we show that the patterns of alternatively spliced SMPD1 transcripts are significantly different in patients with systemic inflammatory response syndrome and severe sepsis/septic shock compared to control subjects allowing discrimination of respective disease entity. The different splicing patterns might contribute to the better understanding of the pathophysiology of human sepsis.

PMID:
25898364
PMCID:
PMC4405572
DOI:
10.1371/journal.pone.0124503
[Indexed for MEDLINE]
Free PMC Article

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