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Breast Cancer Res. 2015 Apr 22;17:58. doi: 10.1186/s13058-015-0570-7.

Common germline polymorphisms associated with breast cancer-specific survival.

Pirie A1, Guo Q2, Kraft P3,4, Canisius S5, Eccles DM6, Rahman N7, Nevanlinna H8, Chen C9, Khan S10, Tyrer J11, Bolla MK12, Wang Q13, Dennis J14, Michailidou K15, Lush M16, Dunning AM17, Shah M18, Czene K19, Darabi H20, Eriksson M21, Lambrechts D22,23, Weltens C24, Leunen K25, van Ongeval C26, Nordestgaard BG27,28,29, Nielsen SF30,31, Flyger H32, Rudolph A33, Seibold P34, Flesch-Janys D35, Blomqvist C36, Aittomäki K37, Fagerholm R8,38,39, Muranen TA40, Olsen JE41, Hallberg E42, Vachon C43, Knight JA44,45, Glendon G46, Mulligan AM47,48, Broeks A49, Cornelissen S50, Haiman CA51, Henderson BE52, Schumacher F53, Le Marchand L54, Hopper JL55, Tsimiklis H56, Apicella C57, Southey MC58, Cross SS59, Reed MW60, Giles GG61,62, Milne RL63,64, McLean C65, Winqvist R66, Pylkäs K67, Jukkola-Vuorinen A68, Grip M69, Hooning MJ70, Hollestelle A71, Martens JW72, van den Ouweland AM73, Marme F74,75, Schneeweiss A76,77, Yang R78, Burwinkel B79,80, Figueroa J81, Chanock SJ82,83, Lissowska J84, Sawyer EJ85, Tomlinson I86, Kerin MJ87, Miller N88, Brenner H89,90, Butterbach K91, Holleczek B92, Kataja V93, Kosma VM94,95, Hartikainen JM96,97, Li J98, Brand JS99, Humphreys K100, Devilee P101, Tollenaar RA102, Seynaeve C103, Radice P104, Peterlongo P105, Manoukian S106, Ficarazzi F107,108, Beckmann MW109, Hein A110, Ekici AB111, Balleine R112, Phillips KA113,114,115; kConFab Investigators, Benitez J116,117, Zamora MP118, Perez JI119, Menéndez P120, Jakubowska A121, Lubinski J122, Gronwald J123, Durda K124, Hamann U125, Kabisch M126, Ulmer HU127, Rüdiger T128, Margolin S129, Kristensen V130,131, Nord S132,133; NBCS Investigators, Evans DG134, Abraham J135,136,137, Earl H138,139, Poole CJ140, Hiller L141, Dunn JA142, Bowden S143, Yang R144, Campa D145,146, Diver WR147, Gapstur SM148, Gaudet MM149, Hankinson S150,151,152, Hoover RN153, Hüsing A154, Kaaks R155, Machiela MJ156, Willett W157, Barrdahl M158, Canzian F159, Chin SF160, Caldas C161,162,163, Hunter DJ164,165, Lindstrom S166,167, Garcia-Closas M168,169, Couch FJ170, Chenevix-Trench G171, Mannermaa A172,173, Andrulis IL174,175, Hall P176, Chang-Claude J177, Easton DF178,179, Bojesen SE180,181,182, Cox A183, Fasching PA184,185, Pharoah PD186,187, Schmidt MK188.

Author information

1
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ap736@medschl.cam.ac.uk.
2
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. qg209@medschl.cam.ac.uk.
3
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. pkraft@hsph.harvard.edu.
4
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. pkraft@hsph.harvard.edu.
5
Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. s.canisius@nki.nl.
6
Faculty of Medicine, University of Southampton, Highfield Campus, Southampton, SO17 1BJ, UK. d.m.eccles@soton.ac.uk.
7
Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, UK. Nazneen.Rahman@icr.ac.uk.
8
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
9
Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. cjchen@hsph.harvard.edu.
10
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. sofia.khan@helsinki.fi.
11
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. jpt34@medschl.cam.ac.uk.
12
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. mkh39@medschl.cam.ac.uk.
13
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. qw232@medschl.cam.ac.uk.
14
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. jgd29@cam.ac.uk.
15
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. km533@medschl.cam.ac.uk.
16
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. mjl81@medschl.cam.ac.uk.
17
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. amd24@medschl.cam.ac.uk.
18
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ms483@medschl.cam.ac.uk.
19
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. kamila.czene@ki.se.
20
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. hatef.darabi@ki.se.
21
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. mikael.eriksson@ki.se.
22
Vesalius Research Center (VRC), Vib, Herestraat 49, 3000, Leuven, Belgium. diether.lambrechts@med.kuleuven.be.
23
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Herestraat 49, 3000, Leuven, Belgium. diether.lambrechts@med.kuleuven.be.
24
Oncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. caroline.weltens@uzleuven.be.
25
Oncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. karin.leunen@uzleuven.be.
26
Oncology Department, University Hospital Gasthuisberg, Herestraat 49, 3000, Leuven, Belgium. Chantal.VanOngeval@uzleuven.be.
27
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. boerge.nordestgaard@regionh.dk.
28
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. boerge.nordestgaard@regionh.dk.
29
Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2220, Copenhagen, Denmark. boerge.nordestgaard@regionh.dk.
30
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. sune.fallgaard.nielsen@regionh.dk.
31
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. sune.fallgaard.nielsen@regionh.dk.
32
Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. henrik.flyger@regionh.dk.
33
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.rudolph@dkfz.de.
34
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. p.seibold@dkfz.de.
35
Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. flesch@uke.uni-hamburg.de.
36
Department of Oncology, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. carl.blomqvist@helsinki.fi.
37
Department of Clinical Genetics, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. kristiina.aittomaki@hus.fi.
38
Department of Oncology, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
39
Department of Clinical Genetics, Helsinki University Central Hospital, Sairaalatie 8, 08 200 LOHJA, Helsinki, Finland. Heli.Nevanlinna@hus.fi.
40
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Haartmaninkatu 8, FIN-00029 HUS, Helsinki, Finland. taru.a.muranen@helsinki.fi.
41
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. olsonj@mayo.edu.
42
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. Hallberg.emily@mayo.edu.
43
Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. vachon.celine@mayo.edu.
44
Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. knight@lunenfeld.ca.
45
Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, 155 College Street, Toronto, ON, M5T 3M7, Canada. knight@lunenfeld.ca.
46
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. gglendon@uhnresearch.ca.
47
Department of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. AnnaMarie.Mulligan@uhn.ca.
48
Laboratory Medicine Program, University Health Network, 200 Elizabeth Street, Toronto, ON, M5G 2C4, Canada. AnnaMarie.Mulligan@uhn.ca.
49
Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. a.broeks@nki.nl.
50
Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. s.cornelissen@nki.nl.
51
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. Christopher.Haiman@med.usc.edu.
52
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. Behender@usc.edu.
53
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 1975 Zonal Avenue, Los Angeles, CA, 90033, USA. fschumac@usc.edu.
54
Cancer Research Center of Hawaii, University of Hawaii, 701 Ilalo Street, Honolulu, HI, 96813, USA. loic@crch.hawaii.edu.
55
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. j.hopper@unimelb.edu.au.
56
Department of Pathology, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. htsi@unimelb.edu.au.
57
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. capic@unimelb.edu.au.
58
Department of Pathology, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. msouthey@unimelb.edu.au.
59
Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, 385a Glossop Road, Sheffield, S10 2HQ, UK. s.s.cross@sheffield.ac.uk.
60
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK. m.w.reed@sheffield.ac.uk.
61
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Graham.Giles@cancervic.org.au.
62
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Graham.Giles@cancervic.org.au.
63
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Roger.Milne@cancervic.org.au.
64
Cancer Epidemiology Centre, The Cancer Council Victoria, 615 St Kilda Road, Melbourne, VIC, 3004, Australia. Roger.Milne@cancervic.org.au.
65
Anatomical Pathology, The Alfred Hospital, Commercial Road, Melbourne, VIC, 3007, Australia. C.McLean@alfred.org.au.
66
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland. robert.winqvist@oulu.fi.
67
Laboratory of Cancer Genetics and Tumor Biology, Department of Clinical Genetics and Biocenter Oulu, University of Oulu, Oulu University Hospital, Kajaanintie 50, FI-90220, Oulu, Finland. katri.pylkas@oulu.fi.
68
Department of Oncology, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220, Oulu, Finland. arja.jukkola-vuorinen@ppshp.fi.
69
Department of Surgery, Oulu University Hospital, University of Oulu, Kajaanintie 50, FI-90220, Oulu, Finland. mervi.grip@ppshp.fi.
70
Department of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. m.hooning@erasmusmc.nl.
71
Department of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.hollestelle@erasmusmc.nl.
72
Department of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. j.martens@erasmusmc.nl.
73
Department of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. a.vandenouweland@erasmusmc.nl.
74
Department of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. frederikmarme@gmail.com.
75
National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. frederikmarme@gmail.com.
76
Department of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. Andreas.Schneeweiss@med.uni-heidelberg.de.
77
National Center for Tumor Diseases, University of Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany. Andreas.Schneeweiss@med.uni-heidelberg.de.
78
Department of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. R.Yang@dkfz.de.
79
Department of Obstetrics and Gynecology, University of Heidelberg, Voßstrasse 9, 69115, Heidelberg, Germany. Barbara.Burwinkel@med.uni-heidelberg.de.
80
Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. Barbara.Burwinkel@med.uni-heidelberg.de.
81
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. figueroaj@mail.nih.gov.
82
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. chanocks@mail.nih.gov.
83
Core Genotyping Facility, Frederick National Laboratory for Cancer Research, 8717 Grovemont Circle, Gaithersburg, MD, 20877, USA. chanocks@mail.nih.gov.
84
Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Roentena 5, 02-781, Warsaw, Poland. lissowsj@coi.waw.pl.
85
Division of Cancer Studies, NIHR Comprehensive Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust in Partnership with King's College London, Guy's Campus, SE1 1UL, London, UK. chanocks@mail.nih.gov.
86
Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. iant@well.ox.ac.uk.
87
Clinical Science Institute, University Hospital Galway, Newcastle Road, Galway, Ireland. michael.kerin@nuigalway.ie.
88
Clinical Science Institute, University Hospital Galway, Newcastle Road, Galway, Ireland. nicola.miller@nuigalway.ie.
89
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. h.brenner@dkfz.de.
90
German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. h.brenner@dkfz.de.
91
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany. k.butterbach@dkfz.de.
92
Saarland Cancer Registry, Präsident Baltz Strasse 5, 66119, Saarbrücken, Germany. b.holleczek@gbe-ekr.saarland.de.
93
School of Medicine, Institute of Clinical Medicine, Oncology and Cancer Center, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. vesa.kataja@kuh.fi.
94
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. veli-matti.kosma@uef.fi.
95
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. veli-matti.kosma@uef.fi.
96
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. jaana.hartikainen@uef.fi.
97
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. jaana.hartikainen@uef.fi.
98
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. jingmei@gmail.com.
99
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. judith.brand@ki.se.
100
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. Keith.Humphreys@ki.se.
101
Department of Human Genetics and Department of Pathology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. p.devilee@lumc.nl.
102
Department of Surgical Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands. r.a.e.m.tollenaar@lumc.nl.
103
Department of Medical Oncology, Family Cancer Clinic, Erasmus McCancer Institute, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. c.seynaeve@erasmusmc.nl.
104
Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), Via Adamello 16, Milan, 20139, Italy. paolo.radice@istitutotumori.mi.it.
105
IFOM, Fondazione Istituto FIRC Di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. paolo.peterlongo@ifom.eu.
106
Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Dei Tumori (INT), Via Adamello 16, Milan, 20139, Italy. siranoush.manoukian@istitutotumori.mi.it.
107
IFOM, Fondazione Istituto FIRC Di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy. filomena.ficarazzi@ifom.eu.
108
Cogentech Cancer Genetic Test Laboratory, Via Adamello 16, 20139, Milan, Italy. filomena.ficarazzi@ifom.eu.
109
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. fk-direktion@uk-erlangen.de.
110
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. alexander.hein@uk-erlangen.de.
111
Institute of Human Genetics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. arif.ekici@uk-erlangen.de.
112
Western Sydney and Nepean Blue Mountains Local Health Districts, Westmead Millennium Institute for Medical Research, University of Sydney, 176 Hawkesbury Road, Sydney, NSW 2145, Australia. rosemary.balleine@sydney.edu.au.
113
Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, Melbourne School of Population Health, The University of Melbourne, 207 Bouverie Street, Melbourne, VIC, 3010, Australia. Kelly.Phillips@petermac.org.
114
Peter Maccallum Cancer Center, 2 St Andrews Place, Melbourne, VIC, 3002, Australia. Kelly.Phillips@petermac.org.
115
Sir Peter Maccallum Department of Oncology, University of Melbourne, 2 St Andrews Place, Melbourne, VIC, 3002, Australia. Kelly.Phillips@petermac.org.
116
Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Calle de Melchor Fernández, Almagro, 3, 28029, Madrid, Spain. jbenitez@cnio.es.
117
Centro de Investigación En Red De Enfermedades Raras (CIBERER), Calle de Álvaro de Bazán, 10 Bajo, 46010, Valencia, Spain. jbenitez@cnio.es.
118
Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana, 261, 28046, Madrid, Spain. zamorapilar@gmail.com.
119
Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Avenida Doctores Fernández Vega, 107, 33012, Oviedo, Spain. jiarias@msn.com.
120
Servicio de Anatomía Patológica, Hospital Monte Naranco, Avenida Doctores Fernández Vega, 107, 33012, Oviedo, Spain. tiva@hca.es.
121
Department of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. aniaj@sci.pam.szczecin.pl.
122
Department of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. lubinski@sci.pam.szczecin.pl.
123
Department of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. jgron@sci.pum.edu.pl.
124
Department of Genetics and Pathology, Pomeranian Medical University, ul. Rybacka 1, Szczecin, Poland. k.durda@onet.pl.
125
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. u.hamann@dkfz-heidelberg.de.
126
Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. m.kabisch@dkfz-heidelberg.de.
127
Frauenklinik der Stadtklinik Baden-Baden, Balger Strasse 50, 76532, Baden-Baden, Germany. hu.ulmer@klinikum-mittelbaden.de.
128
Institute of Pathology, Städtisches Klinikum Karlsruhe, Moltkestrasse 90, 76133, Karlsruhe, Germany. Thomas.Ruediger@klinikum-karlsruhe.de.
129
Department of Oncology - Pathology, Karolinska Institutet, Tomtebodavägen 23b, Stockholm, 171 65, Sweden. Sara.Margolin@karolinska.se.
130
Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Problemveien 7, Oslo, 0313, Norway. Vessela.N.Kristensen@rr-research.no.
131
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Montebello, 0379, Oslo, Norway. Vessela.N.Kristensen@rr-research.no.
132
Faculty of Medicine (Faculty Division Ahus), University of Oslo (UiO), Problemveien 7, Oslo, 0313, Norway. silje.nordgard@gmail.com.
133
Department of Genetics, Institute for Cancer Research, Oslo University Hospital, Radiumhospitalet, Montebello, 0379, Oslo, Norway. silje.nordgard@gmail.com.
134
Genomic Medicine, Manchester Academic Health Science Centre, University of Manchester, Central Manchester Foundation Trust, St. Mary's Hospital, Oxford Road, Manchester, M13 9WL, UK. Gareth.Evans@cmft.nhs.uk.
135
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. ja344@medschl.cam.ac.uk.
136
Cambridge Experimental Cancer Medicine Centre, Robinson Way, Cambridge, CB2 0RE, UK. ja344@medschl.cam.ac.uk.
137
Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Hills Road, Cambridge, CB2 0QQ, UK. ja344@medschl.cam.ac.uk.
138
Cambridge Experimental Cancer Medicine Centre, Robinson Way, Cambridge, CB2 0RE, UK. hme22@cam.ac.uk.
139
Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Hills Road, Cambridge, CB2 0QQ, UK. hme22@cam.ac.uk.
140
Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. christopher.poole@warwick.ac.uk.
141
Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. l.hiller@warwick.ac.uk.
142
Warwick Clinical Trials Unit, University of Warwick, Gibbet Hill Campus, Coventry, CV4 7AL, UK. j.a.dunn@warwick.ac.uk.
143
Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, the University of Birmingham, Vincent Drive, Edgbaston, Birmingham, B15 2TT, UK. s.j.bowden@bham.ac.uk.
144
Early Detection Research Group, Division of Cancer Prevention National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD, 20892, USA. royang@mail.nih.gov.
145
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. d.campa@dkfz-heidelberg.de.
146
Department of Biology, University of Pisa, Lungarno Pacinotti 43, 56126, Pisa, Italy. d.campa@dkfz-heidelberg.de.
147
Epidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Ryan.diver@cancer.org.
148
Epidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Susan.gapstur@cancer.org.
149
Epidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA. Mia.gaudet@cancer.org.
150
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. shankinson@schoolph.umass.edu.
151
Division of Biostatistics and Epidemiology, University of Massachusetts-Amherst School of Public Health and Health Sciences, 715 N Pleasant Street, Amherst, MA, 01002, USA. shankinson@schoolph.umass.edu.
152
Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. shankinson@schoolph.umass.edu.
153
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. hooverr@exchange.nih.gov.
154
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.huesing@dkfz.de.
155
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. r.kaaks@dkfz.de.
156
Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD, 20892, USA. Mitchell.machiela@nih.gov.
157
Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA, 02115, USA. wwillett@hsph.harvard.edu.
158
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. m.barrdahl@Dkfz-Heidelberg.de.
159
Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. f.canzian@dkfz-heidelberg.de.
160
Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, CB2 0RE, UK. Suet-Feung.Chin@cruk.cam.ac.uk.
161
Cambridge Experimental Cancer Medicine Centre, Robinson Way, Cambridge, CB2 0RE, UK. carlos.caldas@cruk.cam.ac.uk.
162
Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, University of Cambridge NHS Foundation Hospitals, Hills Road, Cambridge, CB2 0QQ, UK. carlos.caldas@cruk.cam.ac.uk.
163
Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, CB2 0RE, UK. carlos.caldas@cruk.cam.ac.uk.
164
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. dhunter@hsph.harvard.edu.
165
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. dhunter@hsph.harvard.edu.
166
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. slindstr@hsph.harvard.edu.
167
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA. slindstr@hsph.harvard.edu.
168
Division of Genetics and Epidemiology, Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, Surrey, UK. Montse.GarciaClosas@icr.ac.uk.
169
Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK. Montse.GarciaClosas@icr.ac.uk.
170
Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA. couch.fergus@mayo.edu.
171
Department of Genetics, Qimr Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia. Georgia.Trench@qimrberghofer.edu.au.
172
School of Medicine, Institute of Clinical Medicine, Pathology and Forensic Medicine and Cancer Center of Eastern Finland, University of Eastern Finland, Yliopistonranta 1C, 70210, Kuopio, Finland. arto.mannermaa@uef.fi.
173
Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Puijonlaaksontie 2, 70210, Kuopio, Finland. arto.mannermaa@uef.fi.
174
Ontario Cancer Genetics Network, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. andrulis@lunenfeld.ca.
175
Department of Molecular Genetics, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. andrulis@lunenfeld.ca.
176
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels väg 12A, Stockholm, 17177, Sweden. Per.Hall@ki.se.
177
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. j.chang-claude@dkfz-heidelberg.de.
178
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
179
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. dfe20@medschl.cam.ac.uk.
180
Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
181
Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev Ringvej 75, DK-2730, Herlev, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
182
Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3, DK-2220, Copenhagen, Denmark. stig.egil.bojesen@regionh.dk.
183
CRUK/YCR Sheffield Cancer Research Centre, Department of Oncology, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK. a.cox@shef.ac.uk.
184
Institute of Human Genetics; University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Emn, Universitaetsstrasse 21-23, 91054, Erlangen, Germany. peter.fasching@uk-erlangen.de.
185
David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. peter.fasching@uk-erlangen.de.
186
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. pp10001@medschl.cam.ac.uk.
187
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, 2 Wort's Causeway, Cambridge, CB1 8RN, UK. pp10001@medschl.cam.ac.uk.
188
Netherlands Cancer Institute, Antoni Van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. mk.schmidt@nki.nl.

Abstract

INTRODUCTION:

Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium.

METHODS:

A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect.

RESULTS:

Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease.

CONCLUSIONS:

Although no variants reached genome-wide significance (P <5 x 10(-8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.

PMID:
25897948
PMCID:
PMC4484708
DOI:
10.1186/s13058-015-0570-7
[Indexed for MEDLINE]
Free PMC Article

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