Send to

Choose Destination
Reprod Fertil Dev. 2015 Jul;27(6):969-74. doi: 10.1071/RD14461.

Oogonial stem cells as a model to study age-associated infertility in women.

Author information

Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.


Fertility is the first biological process to break down during aging, thereby making it a useful tool to understand fundamental processes of aging. Reproductive aging in females is associated with a loss of ovarian function characterised by a reduction in the number and quality of oocytes. The central dogma, namely that females are born with a fixed pool of oocytes that progressively decline with increasing maternal age, has been challenged by evidence supporting postnatal oogenesis in mammals. Reports demonstrating formation of new oocytes from newly discovered germline stem cells, referred to as oogonial stem cells (OSCs), has opened new avenues for treatment of female infertility. In this review we discuss why the OSCs possibly lose their regenerative potential over time, and focus specifically on the aging process in germline stem cells as a possible mechanism for understanding female age-related infertility and how we can slow or delay ovarian aging.

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CSIRO Icon for PubMed Central
Loading ...
Support Center