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Bull Exp Biol Med. 2015 Apr;158(6):800-3. doi: 10.1007/s10517-015-2865-1. Epub 2015 Apr 22.

Effects of iron ions and iron chelation on the efficiency of experimental radiotherapy of animals with gliomas.

Author information

1
Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia, sergey.d.ivanov@mail.ru.

Abstract

We evaluated the effect of iron ion chelation on the growth of gliomas and radiotherapy efficiency in tumor-bearing animals. The rats with transplanted glioma-35 received iron-containing water; desferroxamine was injected for metal chelation. Long-term treatment with iron-containing water promoted glioma growth in rats and improved the efficiency of radiotherapy due to combination of apoptosis and ferroptosis. Desferroxamine reduced the efficiency of this treatment and was inessential for the efficiency of radiotherapy alone.

PMID:
25896595
DOI:
10.1007/s10517-015-2865-1
[Indexed for MEDLINE]

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