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Chem Commun (Camb). 2015 May 21;51(41):8618-21. doi: 10.1039/c5cc02204e.

Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.

Author information

1
Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY, USA. les2007@med.cornell.edu.

Abstract

To understand the structural basis for the Na(+)-sensitivity of ligand binding to dopamine D2-like receptors, using computational analysis in combination with binding assays, we identified interactions critical in propagating the impact of Na(+) on receptor conformations and on the ligand-binding site. Our findings expand the pharmacologically-relevant conformational spectrum of these receptors.

PMID:
25896577
PMCID:
PMC5234269
DOI:
10.1039/c5cc02204e
[Indexed for MEDLINE]
Free PMC Article

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