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Spinal Cord. 2015 Aug;53(8):615-20. doi: 10.1038/sc.2015.61. Epub 2015 Apr 21.

Evaluation of serum myostatin and sclerostin levels in chronic spinal cord injured patients.

Author information

1
1] Physical and Rehabilitation Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy [2] Società Italiana per lo Studio delle Disabilità Muscolo-Scheletriche-SISDIM, Novara, Italy.
2
Department of Neurorehabilitation and Neuropsychology, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland.
3
Innovative Research Laboratory for Wound Healing, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.
4
Physical and Rehabilitation Medicine, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.
5
Human Physiology, Department of Traslational Medicine, University of Eastern Piedmont 'A.Avogadro', Novara, Italy.
6
1] Società Italiana per lo Studio delle Disabilità Muscolo-Scheletriche-SISDIM, Novara, Italy [2] Human Physiology, Department of Traslational Medicine, University of Eastern Piedmont 'A.Avogadro', Novara, Italy.
7
1] Società Italiana per lo Studio delle Disabilità Muscolo-Scheletriche-SISDIM, Novara, Italy [2] Innovative Research Laboratory for Wound Healing, Department of Health Sciences, University of Eastern Piedmont 'A. Avogadro', Novara, Italy.

Abstract

STUDY DESIGN:

Case-control study.

OBJECTIVES:

To assess serum myostatin levels, bone mineral density (BMD), appendicular skeletal muscle mass (ASMM) and serum sclerostin levels in chronic spinal cord injured (SCI) patients and healthy controls.

SETTING:

SCI centre in Italy.

METHODS:

Blood samples, whole-body bioelectrical impedance analysis and BMD measurement with the ultrasound technique at the calcaneus level were taken from patients suffering from chronic SCI (both motor complete and incomplete) and healthy control subjects.

RESULTS:

A total of 28 SCI patients and 15 healthy controls were enrolled. Serum myostatin levels were statistically higher (P<0.01) in SCI patients compared with healthy controls. Similar results were found comparing both the motor complete and the motor incomplete SCI subgroups to healthy controls. Serum sclerostin was significantly higher in patients with SCI compared with healthy controls (P<0.01). BMD, stiffness and mean T-score values in SCI patients were significantly lower than those in healthy controls. Serum myostatin concentrations in the motor complete SCI subgroups correlated only with serum sclerostin levels (r(2)=0.42; P=0.001) and ASMM (r(2)=0.70; P=0.002) but not in healthy controls.

DISCUSSION:

Serum myostatin and serum sclerostin are significantly higher in chronic SCI patients compared with healthy controls. They are potential biomarkers of muscle and bone modifications after SCI. This is the first study reporting an increase in serum myostatin in patients suffering from chronic SCI and a correlation with ASMM.

PMID:
25896346
DOI:
10.1038/sc.2015.61
[Indexed for MEDLINE]

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