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Chem Commun (Camb). 2015 May 18;51(40):8547-50. doi: 10.1039/c5cc00186b.

A luminescent cyclometalated gold(iii)-avidin conjugate with a long-lived emissive excited state that binds to proteins and DNA and possesses anti-proliferation capacity.

Author information

1
State Key Laboratory of Synthetic Chemistry, Institute of Molecular Functional Materials, Chemical Biology Center and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. cmche@hku.hk.

Abstract

Here we describe a luminescent cyclometalated Au(iii)-avidin conjugate that exhibits a 520 nm emission with a lifetime of 1.8 μs in PBS solution in open air. The conjugate stains proteins and DNA and can inhibit cancer cell proliferation.

PMID:
25896112
DOI:
10.1039/c5cc00186b
[Indexed for MEDLINE]

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