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FEBS Lett. 2015 May 22;589(12):1359-68. doi: 10.1016/j.febslet.2015.04.010. Epub 2015 Apr 17.

Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats.

Author information

1
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
2
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: yanwei@tjh.tjmu.edu.cn.
3
Department of Gastroenterology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: datian@tjh.tjmu.edu.cn.

Abstract

Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis.

KEYWORDS:

Hepatic stellate cell; Liver fibrosis; Ras/Raf-1/MEK/ERK/Ets-1; SATB1

PMID:
25896016
DOI:
10.1016/j.febslet.2015.04.010
[Indexed for MEDLINE]
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