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J Infect Dis. 2015 Nov 1;212(9):1397-401. doi: 10.1093/infdis/jiv233. Epub 2015 Apr 20.

CCR5 Expression Levels in HIV-Uninfected Women Receiving Hormonal Contraception.

Author information

1
Ragon Institute of MGH, MIT, and Harvard, Boston, Massachusetts.
2
Georgetown University Medical Center, Washington D.C.
3
Department of Medicine, Albert Einstein College of Medicine, Bronx Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx.
4
Department of Obstetrics and Gynecology, Division of Reproductive Biology, New York University School of Medicine, New York.
5
Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles.
6
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles.
7
Department of Clinical Pharmacy, University of California, San Francisco Department of Medicine, University of California, San Francisco Department of Biostatistics, University of California, San Francisco Department of Epidemiology, University of California, San Francisco.
8
Department of Medicine, Stroger Hospital Department of Medicine, Rush University CORE Center, Chicago, Illinois.
9
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore.
10
The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
11
Brigham and Women's Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts.

Abstract

Human immunodeficiency virus (HIV) infectivity increases as receptor/coreceptor expression levels increase. We determined peripheral CD4, CCR5, and CXCR4 expression levels in HIV-uninfected women who used depot medroxyprogesterone acetate (DMPA; n = 32), the levonorgestrel-releasing intrauterine device (LNG-IUD; n = 27), oral contraceptive pills (n = 32), or no hormonal contraception (n = 33). The use of LNG-IUD increased the proportion of CD4(+) and CD8(+) T cells that expressed CCR5; increases in the magnitude of T-cell subset CCR5 expression were observed with DMPA and LNG-IUD use (P < .01 for all comparisons). LNG-IUD and, to a lesser extent, DMPA use were associated with increased peripheral T-cell CCR5 expression.

KEYWORDS:

CCR5; CD4; CXCR4; HIV-1; hormonal contraception; levonorgestrel; medroxyprogesterone acetate; oral contraceptive pills; peripheral blood mononuclear cells

PMID:
25895986
PMCID:
PMC4601918
DOI:
10.1093/infdis/jiv233
[Indexed for MEDLINE]
Free PMC Article

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