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PLoS One. 2015 Apr 20;10(4):e0123696. doi: 10.1371/journal.pone.0123696. eCollection 2015.

Association of VEGF genetic polymorphisms with recurrent spontaneous abortion risk: a systematic review and meta-analysis.

Author information

1
Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China; Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China.
2
Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, 252000, China.
3
Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200127, China.
4
Department of Gynecology and Obstetrics, Tianjin third central hospital, Tianjin, 300170, China.
5
Department of Gynecology and Obstetrics, Liaocheng People's Hospital, Liaocheng, 252000, China.
6
Department of Hematology, Liaocheng People's Hospital, Liaocheng, 252000, China.
7
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, 250021, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, 250021, China; The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, 250021, China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, 200127, China.

Abstract

BACKGROUND:

Studies of the associations between the genetic polymorphisms of the vascular endothelial growth factor (VEGF) gene and recurrent spontaneous abortion (RSA) have revealed conflicting results. The present meta-analysis was performed to provide a more precise estimation of these relationships and to explore potential sources of heterogeneity that may have influenced the reported disparities.

METHODS:

An extensive literature search for relevant studies was conducted on PubMed, Embase, and The Cochrane Library through June 6, 2014. Crude odds ratio (OR) with 95% confidence intervals were calculated.

RESULTS:

10 case-control studies including 1,832 RSA patients and 2,271 healthy controls were identified. Meta-analysis indicated that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms in the VEGF gene correlated with elevated RSA risk. The rs1570360 variant was statistically significantly relevant to RSA risk among non-Asian populations. Interestingly, the rs3025039 variant was statistically significantly relevant to RSA risk among Asian populations.

CONCLUSIONS:

The current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms increase RSA susceptibility. Moreover, rs1570360 and rs3025039 polymorphisms may play various roles in RSA susceptibility in various geographic groups.

PMID:
25894555
PMCID:
PMC4404341
DOI:
10.1371/journal.pone.0123696
[Indexed for MEDLINE]
Free PMC Article

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