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Alzheimers Dement (Amst). 2015 Mar 1;1(1):14-23.

Hippocampal subfield surface deformity in non-semantic primary progressive aphasia.

Author information

1
Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
2
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
3
Biomedical Engineering, Simon Fraser University, BC, Canada.
4
Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Cognitive Neurology and Alzheimer's Disease Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.
5
Department of Psychiatry and Behavioral Sciences, Division of Clinical Psychology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 ; Department of Radiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611.

Abstract

BACKGROUND:

Alzheimer neuropathology (AD) is found in almost half of patients with non-semantic primary progressive aphasia (PPA). This study examined hippocampal abnormalities in PPA to determine similarities to those described in amnestic AD.

METHODS:

In 37 PPA patients and 32 healthy controls, we generated hippocampal subfield surface maps from structural MRIs and administered a face memory test. We analyzed group and hemisphere differences for surface shape measures and their relationship with test scores and ApoE genotype.

RESULTS:

The hippocampus in PPA showed inward deformity (CA1 and subiculum subfields) and outward deformity (CA2-4+DG subfield) and smaller left than right volumes. Memory performance was related to hippocampal shape abnormalities in PPA patients, but not controls, even in the absence of memory impairments.

CONCLUSIONS:

Hippocampal deformity in PPA is related to memory test scores. This may reflect a combination of intrinsic degenerative phenomena with transsynaptic or Wallerian effects of neocortical neuronal loss.

KEYWORDS:

Alzheimer’s disease (AD); frontotemporal dementia; lobar degeneration; memory; multi-atlas mapping; neuroanatomy; primary progressive aphasia (PPA); structural magnetic resonance imaging (MRI)

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