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Lab Chip. 2015 May 21;15(10):2308-17. doi: 10.1039/c5lc00178a.

Point-of-care diagnostics for ricin exposure.

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CEA, IRTSV, Biologie à Grande Echelle, 17 rue des Martyrs, F-38054, Grenoble, Cedex 9, France.


A long-sought milestone in the defense against bioterrorism is the development of rapid, simple, and near-patient assays for diagnostic and theranostic purposes. Here, we present a powerful test based on a host response to a biological weapon agent, namely the ricin toxin. A signature for exposure to ricin was extracted and characterized in mice and then integrated into a plastic microfluidic cartridge. This enabled early diagnosis of exposure to ricin in mice using a drop of whole blood in less than 1 h and 30 min. The cartridge stores the reagents and implements all of the steps of the analysis, including mRNA extraction from a drop of blood, followed by tens of parallel RT-qPCR reactions. The simple and low-cost microfluidic cartridge developed here may find other applications in point-of-care diagnostics.

[Indexed for MEDLINE]

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