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Transplant Proc. 2015 Apr;47(3):738-41. doi: 10.1016/j.transproceed.2014.12.031.

Viability and functional assessment of murine pancreatic islets after transportation between Korea and Japan.

Author information

1
Regenerative Medicine Laboratory, Center for Stem Cell Research, Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea.
2
Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
3
Department of Regenerative Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan; Project Leader of Advanced Medical Research Center, Yokohama City University, Yokohama, Japan; PRESTO, Japan Science and Technology Agency, Saitama, Japan.
4
Regenerative Medicine Laboratory, Center for Stem Cell Research, Department of Biomedical Science and Technology, Institute of Biomedical Science and Technology, Konkuk University, Seoul, Republic of Korea; Department of Veterinary Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea. Electronic address: jeongik@konkuk.ac.kr.

Erratum in

Abstract

BACKGROUND:

Organ donor scarcity remains a restricting factor for pancreatic islet transplantation. To date, limited information is available on the impact of long-distance transportation on transplantable pancreatic islets. The objective of this study was to assess the effects of transportation on the viability and function of murine pancreatic islet cells.

METHODS:

The isolated murine pancreatic islets were transported from Japan to Korea with the use of commercial modes of transportation: subway and commercial airplane. After transportation, the islets were assessed by performing a viability assay and by evaluating the islets' insulin secretion in response to glucose stimulation. A comparative study was performed for evaluating the insulin secretory responses of transported and control islets (not transported).

RESULTS:

There was no evidence of contamination in the transported pancreatic islets. No significant differences were observed in the viability and functionality of the transported and control islet cells.

CONCLUSIONS:

These findings show the feasibility of pancreatic islet transportation from Japan to Korea. Our data could be used not only for the inter-Asian but also for global advancement of animal and human islet transportation methods and transplantation research.

[Indexed for MEDLINE]

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