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J Am Acad Dermatol. 2015 May;72(5):749-58; quiz 759-60. doi: 10.1016/j.jaad.2014.08.028.

Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors.

Author information

1
Division of Dermatology, University of California San Diego, San Diego, California.
2
Division of Dermatology, University of California San Diego, San Diego, California. Electronic address: thata@mail.ucsd.edu.

Abstract

Rosacea is a chronic inflammatory skin condition that affects approximately 16 million Americans. Four distinct subtypes of rosacea have been recognized, with transient and nontransient facial flushing, telangiectasia, and inflammatory papules and pustules being among the more commonly recognized features. Although the exact pathogenesis of rosacea is unknown, dysregulation of the innate immune system, overgrowth of commensal skin organisms, and aberrant neurovascular signaling may all have a role in promoting the clinical features of rosacea.

KEYWORDS:

cathelicidin; mast cells; matrix metalloproteinases; microbiome; rosacea; serine proteases; transient receptor potential channels; ultraviolet radiation

PMID:
25890455
DOI:
10.1016/j.jaad.2014.08.028
[Indexed for MEDLINE]

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