Format

Send to

Choose Destination
Arthritis Res Ther. 2015 Mar 28;17:85. doi: 10.1186/s13075-015-0602-9.

Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population.

Sheng YJ1,2,3,4, Xu JH5, Wu YG6, Zuo XB7,8,9,10, Gao JP11,12,13,14, Lin Y15,16,17,18, Zhu ZW19,20,21,22, Wen LL23,24,25,26, Yang C27,28,29,30, Liu L31,32,33,34, Cheng YY35,36,37,38, Chang Y39,40,41,42, Yang LL43,44,45,46, Zhou FS47,48,49,50, Tang XF51,52,53,54, Zheng XD55,56,57,58, Yin XY59,60,61,62, Tang HY63,64,65,66, Sun LD67,68,69,70, Cui Y71,72,73,74,75, Yang S76,77,78,79, Zhang XJ80,81,82,83.

Author information

1
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. ahmusyj@163.com.
2
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. ahmusyj@163.com.
3
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. ahmusyj@163.com.
4
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. ahmusyj@163.com.
5
Department of Rheumatology and Immunology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, 230032, China. xujianhua@sina.com.
6
Department of Nephrology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, 230032, China. wuyonggui1966@163.com.
7
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 28080806@qq.com.
8
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 28080806@qq.com.
9
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 28080806@qq.com.
10
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 28080806@qq.com.
11
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 591671350@qq.com.
12
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 591671350@qq.com.
13
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 591671350@qq.com.
14
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 591671350@qq.com.
15
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 272599265@qq.com.
16
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 272599265@qq.com.
17
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 272599265@qq.com.
18
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 272599265@qq.com.
19
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 631183574@qq.com.
20
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 631183574@qq.com.
21
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 631183574@qq.com.
22
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 631183574@qq.com.
23
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 361702267@qq.com.
24
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 361702267@qq.com.
25
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 361702267@qq.com.
26
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 361702267@qq.com.
27
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 634713953@qq.com.
28
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 634713953@qq.com.
29
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 634713953@qq.com.
30
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 634713953@qq.com.
31
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 501335910@qq.com.
32
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 501335910@qq.com.
33
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 501335910@qq.com.
34
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 501335910@qq.com.
35
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 1552964678@qq.com.
36
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 1552964678@qq.com.
37
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 1552964678@qq.com.
38
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 1552964678@qq.com.
39
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 458210265@qq.com.
40
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 458210265@qq.com.
41
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 458210265@qq.com.
42
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 458210265@qq.com.
43
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. 892319580@qq.com.
44
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. 892319580@qq.com.
45
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. 892319580@qq.com.
46
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. 892319580@qq.com.
47
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. biozhoufs@163.com.
48
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. biozhoufs@163.com.
49
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. biozhoufs@163.com.
50
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. biozhoufs@163.com.
51
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. xianfatang@hotmail.com.
52
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. xianfatang@hotmail.com.
53
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. xianfatang@hotmail.com.
54
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. xianfatang@hotmail.com.
55
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. zhengxiaodong.1234@163.com.
56
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. zhengxiaodong.1234@163.com.
57
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. zhengxiaodong.1234@163.com.
58
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. zhengxiaodong.1234@163.com.
59
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. yinxianyong1746@163.com.
60
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. yinxianyong1746@163.com.
61
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. yinxianyong1746@163.com.
62
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. yinxianyong1746@163.com.
63
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. tanghuayang@hotmail.com.
64
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. tanghuayang@hotmail.com.
65
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. tanghuayang@hotmail.com.
66
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. tanghuayang@hotmail.com.
67
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. ahmusld@163.com.
68
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. ahmusld@163.com.
69
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. ahmusld@163.com.
70
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. ahmusld@163.com.
71
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. wuhucuiyong@vip.163.com.
72
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. wuhucuiyong@vip.163.com.
73
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. wuhucuiyong@vip.163.com.
74
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. wuhucuiyong@vip.163.com.
75
Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China. wuhucuiyong@vip.163.com.
76
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. yangsen@medmail.com.cn.
77
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. yangsen@medmail.com.cn.
78
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. yangsen@medmail.com.cn.
79
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. yangsen@medmail.com.cn.
80
Institute of Dermatology and Department of Dermatology, No.1 Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China. ayzxj@vip.sina.com.
81
Key Laboratory of Dermatology, Anhui Medical University, Ministry of Education, China, Hefei, Anhui, 230032, China. ayzxj@vip.sina.com.
82
State Key Laboratory Incubation Base of Dermatology, Anhui Medical University, Hefei, Anhui, 230032, China. ayzxj@vip.sina.com.
83
Collaborative Innovation Center for Complex and Severe Dermatosis, Anhui Medical University, Hefei, Anhui, 230032, China. ayzxj@vip.sina.com.

Abstract

INTRODUCTION:

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE susceptibility in this study.

METHODS:

Forty nine single nucleotide polymorphisms (SNPs) with moderate-risk for SLE in previous study were genotyped in a large-scale replication study with a total of 3,522 cases and 8,252 controls using the Sequenom Massarray system. Association analyses were performed using logistic regression with gender or sample cohorts as a covariate through PLINK 1.07 software.

RESULTS:

This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs1418190, odds ratio (OR) = 0.81, P(meta) = 1.08 × 10(-08); rs4916219, OR = 0.80, P(meta )= 7.77 × 10(-09)), IRF8 (rs2934498, OR = 1.25, P(meta) = 4.97 × 10(-09)), miR-146a (rs2431697, OR = 0.69, P(meta) = 1.15 × 10(-22)), CD44 (rs2732547, OR = 0.82, P(meta) = 1.55 × 10(-11)), and TMEM39A (rs12494314, OR = 0.84, P(meta) = 1.01 × 10(-09)). Further logistic regression analysis indicated that the genetic effects within TNFSF4 detected in this study are independent from our previously reported signals.

CONCLUSIONS:

This study increases the number of established susceptibility loci for SLE in Han Chinese population and highlights the contribution of multiple variants of modest effect. Although further studies will be required to identify the causal alleles within these loci, the findings make a significant step forward in our understanding of the genetic contribution to SLE in Chinese population.

PMID:
25890262
PMCID:
PMC4404072
DOI:
10.1186/s13075-015-0602-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center