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FEBS Lett. 2015 May 22;589(12):1376-82. doi: 10.1016/j.febslet.2015.04.003. Epub 2015 Apr 15.

EGFR/ERBB receptors differentially modulate sebaceous lipogenesis.

Author information

1
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
2
Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, Rome, Italy.
3
Human Biology and BioImaging, Department of Biology II, LMU Munich, Germany.
4
Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Dessau, Germany.
5
Institute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany. Electronic address: marlon.schneider@lmu.de.

Abstract

The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis. Nile red staining showed that siRNA-mediated downregulation of EGFR or ERBB3 increases lipid accumulation, whereas ERBB2 downregulation has no effect. Spectrometry confirmed induction of triglycerides after EGFR or ERBB3 downregulation and revealed induction of cholesteryl esters after downregulation of EGFR, ERBB2 or ERBB3. Thus, EGFR/ERBB receptors differentially modulate sebaceous lipogenesis, a key feature of sebaceous gland physiology and of several skin diseases.

KEYWORDS:

ERBB; Epidermal growth factor receptor; Sebaceous gland; Sebaceous lipogenesis

PMID:
25889637
DOI:
10.1016/j.febslet.2015.04.003
[Indexed for MEDLINE]
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