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J Pediatr Surg. 2015 Jun;50(6):963-6. doi: 10.1016/j.jpedsurg.2015.03.019. Epub 2015 Apr 1.

The utility of the contrast enema in neonates with suspected Hirschsprung disease.

Author information

1
Center for Surgical Trials and Evidence-based Practice, Department of Pediatric Surgery, The University of Texas Health Science Center at Houston, TX; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX.
2
Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX; Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, 6431 Fannin Street, MSB 2.130B, Houston, TX.
3
Center for Surgical Trials and Evidence-based Practice, Department of Pediatric Surgery, The University of Texas Health Science Center at Houston, TX; Children's Memorial Hermann Hospital, 6411 Fannin Street, Houston, TX. Electronic address: kuojen.tsao@uth.tmc.edu.

Abstract

BACKGROUND/PURPOSE:

The contrast enema (CE) is commonly utilized for suspected Hirschsprung disease (HD) patients. We set out to determine the utility of the CE in the newborn for clinically suspicious HD.

METHODS:

All CEs performed for suspicion of HD in neonates from January 2004 to December 2013 were reviewed by two pediatric radiologists who were blinded to the original interpretations and final diagnoses. A standardized scoring sheet was utilized to document essential radiographic findings. Definitive diagnoses were determined by pathology. Descriptive statistics, likelihood ratios, and interrater agreement were determined.

RESULTS:

158 CEs were reviewed. Interrater agreement was 89% with kappa (95% CI) of 0.63 (0.47-0.76). Common indications for CE were similar between non-HD and HD groups. The positive, inconclusive, and negative likelihood ratios (95% CI) were 38 (10-172), 3.2 (1.3-9.1), and 0.15 (0.06-0.47), respectively, leading to posttest probabilities for positive, inconclusive, and negative tests of 83%, 32%, and 2.5%, respectively.

CONCLUSIONS:

Although radiographic positive CE for HD portends a high probability of HD, inconclusive studies still represent a significant increased risk. In clinically suspicious infants for HD, those with inconclusive studies may benefit from a lower threshold to perform follow-up rectal biopsy.

KEYWORDS:

Barium enema; Contrast enema; Hirschsprung disease

PMID:
25888274
DOI:
10.1016/j.jpedsurg.2015.03.019
[Indexed for MEDLINE]

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