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Genet Sel Evol. 2015 Feb 22;47:7. doi: 10.1186/s12711-014-0080-6.

Genome-wide QTL analysis of meat quality-related traits in a large F2 intercross between Landrace and Korean native pigs.

Cho IC1, Yoo CK2,3, Lee JB4,5, Jung EJ6,7, Han SH8, Lee SS9, Ko MS10, Lim HT11,12, Park HB13,14,15.

Author information

1
Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. choic4753@korea.kr.
2
Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. yck1985@gnu.ac.kr.
3
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. yck1985@gnu.ac.kr.
4
Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. bilf@gnu.ac.kr.
5
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. bilf@gnu.ac.kr.
6
Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. ejjung@gnu.ac.kr.
7
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. ejjung@gnu.ac.kr.
8
Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. hansh04@naver.com.
9
Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. lee6470@korea.kr.
10
Subtropical Animal Experiment Station, National Institute of Animal Science, Rural Development Administration, Jeju, 690-150, Korea. koms21c@korea.kr.
11
Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. s_htim@gnu.ac.kr.
12
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. s_htim@gnu.ac.kr.
13
Department of Animal Science, College of Agriculture and Life Sciences, Gyeongsang National University, Jinju, 660-701, Korea. heebok.park@cnu.ac.kr.
14
Institute of Agriculture and Life Science, Gyeongsang National University, Jinju, 660-701, Korea. heebok.park@cnu.ac.kr.
15
Department of Animal Science and Biotechnology (BK21 plus program), College of Agriculture and Life Sciences, Chungnam National University, Daejeon, 305-764, Korea. heebok.park@cnu.ac.kr.

Abstract

BACKGROUND:

We conducted a genome-wide linkage analysis to identify quantitative trait loci (QTL) that influence meat quality-related traits in a large F2 intercross between Landrace and Korean native pigs. Thirteen meat quality-related traits of the m. longissimus lumborum et thoracis were measured in more than 830 F2 progeny. All these animals were genotyped with 173 microsatellite markers located throughout the pig genome, and the GridQTL program based on the least squares regression model was used to perform the QTL analysis.

RESULTS:

We identified 23 genome-wide significant QTL in eight chromosome regions (SSC1, 2, 6, 7, 9, 12, 13, and 16) (SSC for Sus Scrofa) and detected 51 suggestive QTL in the 17 chromosome regions. QTL that affect 10 meat quality traits were detected on SSC12 and were highly significant at the genome-wide level. In particular, the QTL with the largest effect affected crude fat percentage and explained 22.5% of the phenotypic variance (F-ratio = 278.0 under the additive model, nominal P = 5.5 × 10(-55)). Interestingly, the QTL on SSC12 that influenced meat quality traits showed an obvious trend for co-localization.

CONCLUSIONS:

Our results confirm several previously reported QTL. In addition, we identified novel QTL for meat quality traits, which together with the associated positional candidate genes improve the knowledge on the genetic structure that underlies genetic variation for meat quality traits in pigs.

PMID:
25888076
PMCID:
PMC4336478
DOI:
10.1186/s12711-014-0080-6
[Indexed for MEDLINE]
Free PMC Article

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