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Int Immunopharmacol. 2015 Oct;28(2):836-40. doi: 10.1016/j.intimp.2015.03.053. Epub 2015 Apr 14.

The nuclear IκB family of proteins controls gene regulation and immune homeostasis.

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Laboratory of Cell Recognition and Response, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan; School of Medicine Gifu University, Gifu 501-1194, Japan. Electronic address:


The inhibitory IκB family of proteins is subdivided into two groups based on protein localization in the cytoplasm or in the nucleus. These proteins interact with NF-κB, a major transcription factor regulating the expression of many inflammatory cytokines, by modulating its transcriptional activity. However, nuclear IκB family proteins not only interact with NF-κB to change its transcriptional activity, but they also bind to chromatin and control gene expression. This review provides an overview of nuclear IκB family proteins and their role in immune homeostasis.


Gene regulation; Immune homeostasis; NF-κB; Nuclear IκB family proteins; Transcriptional factor

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