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Crit Care. 2015 Apr 17;19:169. doi: 10.1186/s13054-015-0900-2.

Acute kidney injury after cardiac arrest.

Author information

1
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. omartujjar@hotmail.com.
2
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. giuliamineo@hotmail.it.
3
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. anthosdel@yahoo.it.
4
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. bpoyatosrobles83@gmail.com.
5
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. katia_doc@yahoo.it.
6
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. scolletta@unisit.it.
7
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. jlvincen@ulb.ac.be.
8
Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, Brussels, 1070, Belgium. ftaccone@ulb.ac.be.

Abstract

INTRODUCTION:

The aim of this study was to evaluate the incidence and determinants of AKI in a large cohort of cardiac arrest patients.

METHODS:

We reviewed all patients admitted, for at least 48 hours, to our Dept. of Intensive Care after CA between January 2008 and October 2012. AKI was defined as oligo-anuria (daily urine output <0.5 ml/kg/h) and/or an increase in serum creatinine (≥0.3 mg/dl from admission value within 48 hours or a 1.5 time from baseline level). Demographics, comorbidities, CA details, and ICU interventions were recorded. Neurological outcome was assessed at 3 months using the Cerebral Performance Category scale (CPC 1-2 = favorable outcome; 3-5 = poor outcome).

RESULTS:

A total of 199 patients were included, 85 (43%) of whom developed AKI during the ICU stay. Independent predictors of AKI development were older age, chronic renal disease, higher dose of epinephrine, in-hospital CA, presence of shock during the ICU stay, a low creatinine clearance (CrCl) on admission and a high cumulative fluid balance at 48 hours. Patients with AKI had higher hospital mortality (55/85 vs. 57/114, p = 0.04), but AKI was not an independent predictor of poor 3-month neurological outcome.

CONCLUSIONS:

AKI occurred in more than 40% of patients after CA. These patients had more severe hemodynamic impairment and needed more aggressive ICU therapy; however the development of AKI did not influence neurological recovery.

PMID:
25887258
PMCID:
PMC4416259
DOI:
10.1186/s13054-015-0900-2
[Indexed for MEDLINE]
Free PMC Article

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