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Biol Direct. 2015 Mar 29;10:12. doi: 10.1186/s13062-015-0047-8.

Plant viruses of the Amalgaviridae family evolved via recombination between viruses with double-stranded and negative-strand RNA genomes.

Author information

1
Department of Microbiology, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, 75015, France. krupovic@pasteur.fr.
2
Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR, 97331, USA. doljav@science.oregonstate.edu.
3
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA. koonin@ncbi.nlm.nih.gov.

Abstract

Plant viruses of the recently recognized family Amalgaviridae have monopartite double-stranded (ds) RNA genomes and encode two proteins: an RNA-dependent RNA polymerase (RdRp) and a putative capsid protein (CP). Whereas the RdRp of amalgaviruses has been found to be most closely related to the RdRps of dsRNA viruses of the family Partitiviridae, the provenance of their CP remained obscure. Here we show that the CP of amalgaviruses is homologous to the nucleocapsid proteins of negative-strand RNA viruses of the genera Phlebovirus (Bunyaviridae) and Tenuivirus. The chimeric genomes of amalgaviruses are a testament to the effectively limitless gene exchange between viruses that shaped the evolution of the virosphere.

PMID:
25886840
PMCID:
PMC4377212
DOI:
10.1186/s13062-015-0047-8
[Indexed for MEDLINE]
Free PMC Article

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