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J Mol Cell Cardiol. 2015 Jun;83:32-6. doi: 10.1016/j.yjmcc.2015.04.008. Epub 2015 Apr 14.

Cardiac aging - Getting to the stem of the problem.

Author information

1
Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: nirmala.hariharan@gmail.com.
2
Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: heartman4ever@icloud.com.

Abstract

Cardiac aging is a heterogeneous process caused by a combination of stochastic events which manifests as loss of structure and function in the heart, however several recent studies draw attention to aging being primarily a stem cell problem. This review summarizes findings in support of the "stem cell hypothesis of aging" and discusses the impact of age on cardiac stem cells and the niche. This article is part of a Special Issue entitled 'CV Aging'.

KEYWORDS:

Aging; Cardiac stem/progenitor cells; Heart

PMID:
25886698
PMCID:
PMC4459886
DOI:
10.1016/j.yjmcc.2015.04.008
[Indexed for MEDLINE]
Free PMC Article

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