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BMC Med. 2015 Apr 8;13:76. doi: 10.1186/s12916-015-0307-6.

Altered pathways and colorectal cancer prognosis.

Author information

1
Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL) and Consortium for Biomedical Research in Epidemiology and Public Health (CIBEResp), Barcelona, Spain. v.moreno@iconcologia.net.
2
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain. v.moreno@iconcologia.net.
3
Cancer Prevention and Control Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL) and Consortium for Biomedical Research in Epidemiology and Public Health (CIBEResp), Barcelona, Spain. rebecasanz@iconcologia.net.

Abstract

The identification of molecular markers with prognostic value in colorectal cancer is a challenging task that is needed to define therapeutic guidelines. Clinical factors are insufficient to identify those patients with stage II at risk of relapse or those patients with stage III at low risk. There is a current effort to define a consensus in molecular subtypes based on expression profiles, which are characterized by a distinctive prognostic outcome. Also several gene expression signatures based on individual genes have been proposed to predict prognosis, but they show low consistency and reproducibility. Slattery et al. describe a pathway-based approach to analyze gene expression differences between normal and colon cancer tissues. The most interesting finding is that having more deregulated pathways is associated with good prognosis. If these findings are properly validated, new insights into the mechanisms of colon carcinogenesis may be revealed. Please see related article: http://dx.doi.org/10.1186/s12916-015-0292-9 .

PMID:
25885526
PMCID:
PMC4389340
DOI:
10.1186/s12916-015-0307-6
[Indexed for MEDLINE]
Free PMC Article

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