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PLoS One. 2015 Apr 17;10(4):e0124394. doi: 10.1371/journal.pone.0124394. eCollection 2015.

Testing initiatives increase rates of HIV diagnosis in primary care and community settings: an observational single-centre cohort study.

Author information

1
Department of GU Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.
2
Clinical Investigations and Research Unit, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom.
3
Brighton and Sussex Medical School, Brighton, United Kingdom.
4
Department of GU Medicine, Brighton and Sussex University Hospitals NHS Trust, Brighton, United Kingdom; Brighton and Sussex Medical School, Brighton, United Kingdom.

Abstract

OBJECTIVES:

The primary objective was to examine trends in new HIV diagnoses in a UK area of high HIV prevalence between 2000 and 2012 with respect to site of diagnosis and stage of HIV infection.

DESIGN:

Single-centre observational cohort study.

SETTING:

An outpatient HIV department in a secondary care UK hospital.

PARTICIPANTS:

1359 HIV-infected adults.

MAIN OUTCOME MEASURES:

Demographic information (age, gender, ethnicity, and sexual orientation), site of initial HIV diagnosis (Routine settings such as HIV/GUM clinics versus Non-Routine settings such as primary care and community venues), stage of HIV infection, CD4 count and seroconversion symptoms were collated for each participant.

RESULTS:

There was a significant increase in the proportion of new HIV diagnoses made in Non-Routine settings (from 27.0% in 2000 to 58.8% in 2012; p<0.001). Overall there was a decrease in the rate of late diagnosis from 50.7% to 32.9% (p=0.001). Diagnosis of recent infection increased from 23.0% to 47.1% (p=0.001). Of those with recent infection, significantly more patients were likely to report symptoms consistent with a seroconversion illness over the 13 years (17.6% to 65.0%; p<0.001).

CONCLUSIONS:

This is the first study, we believe, to demonstrate significant improvements in HIV diagnosis and a shift in diagnosis of HIV from HIV/GUM settings to primary practice and community settings due to multiple initiatives.

PMID:
25885092
PMCID:
PMC4401513
DOI:
10.1371/journal.pone.0124394
[Indexed for MEDLINE]
Free PMC Article

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