Format

Send to

Choose Destination
See comment in PubMed Commons below
BMC Cancer. 2015 Mar 28;15:195. doi: 10.1186/s12885-015-1204-2.

Pre-treatment neutrophil to lymphocyte ratio may be a useful tool in predicting survival in early triple negative breast cancer patients.

Author information

1
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. mirco.pistelli@alice.it.
2
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. mgrazia.delisa@gmail.com.
3
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. zelmira.ballatore@gmail.com.
4
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. miriam.caramanti@libero.it.
5
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. alessandrapagliacci@virgilio.it.
6
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. battellin@gmail.com.
7
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. francesca.ridolfi1@gmail.com.
8
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. mattymo@alice.it.
9
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. elena.maccaroni@live.it.
10
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. raffaellabracci@libero.it.
11
Anatomia Patologica, AO Ospedali Riuniti-Ancona, Università Politecnica delle Marche, Ancona, Italy. a.santinelli@univpm.it.
12
Anatomia Patologica, AO Ospedali Riuniti-Ancona, Università Politecnica delle Marche, Ancona, Italy. biscottit@libero.it.
13
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. r.berardi@univpm.it.
14
Clinica di Oncologia Medica, Università Politecnica delle Marche, Ancona, AO Ospedali Riuniti-Ancona, Italy. cascinu@yahoo.com.

Abstract

BACKGROUND:

There is a growing body of evidence that immune response plays a large role in cancer outcome. The neutrophil to lymphocyte ratio (NLR) has been used as a simple parameter of systemic inflammation in several tumors. The purpose was to investigate the association between pre-treatment NLR, disease-free survival and overall survival in patients with early triple negative breast cancer (TNBC).

METHODS:

We reviewed the records of patients with stage I-III TNBC at our Institution from 2006 to 2012. The association between pre-treatment NLR and survival was analyzed. The difference among variables was calculated by chi-square test. DFS and OS were estimated using Kaplan-Meier method. Cox analysis was performed to analyze clinical parameters for their prognostic relevance.

RESULTS:

A total of 90 patients were eligible. There was no significant correlation among pre-treatment NLR and various clinical pathological factors. Patients with NLR higher than 3 showed significantly lower DFS (p = 0.002) and OS (p = 0.009) than patients with NLR equal or lower than 3. The Cox proportional multivariate hazard model revealed that higher pre-treatment NLR was independently correlated with poor DFS and OS, with hazard ratio 5.15 (95% confidence interval [CI] 1.11-23.88, p = 0.03) and 6.16 (95% CI 1.54-24.66, p = 0.01) respectively.

CONCLUSION:

Our study suggests that pre-treatment NLR may be associated with DFS and OS patients with early TNBC. Further validation and a feasibility study are required before it can be considered for clinical use.

PMID:
25884918
PMCID:
PMC4428113
DOI:
10.1186/s12885-015-1204-2
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center