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PLoS One. 2015 Apr 17;10(4):e0122651. doi: 10.1371/journal.pone.0122651. eCollection 2015.

Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell lung cancer (NSCLC) in Croatian and Norwegian populations.

Author information

1
Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway.
2
Department of Chemical and Biological Working Environment, National Institute of Occupational Health, Oslo, Norway.
3
Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, Norway; Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
4
Institute for Transfusion Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
5
Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, University of Rijeka, Rijeka, Croatia.
6
Department for Biology and Medical Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
7
Department of Clinical Sciences, University of Bergen, Bergen, Norway.

Abstract

We analyzed for associations between a variable number of tandem repeat (VNTR) polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was significantly increased in the patients compared to the healthy controls in the Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the FAM46A gene were significantly decreased in the patients compared to the healthy controls in the Croatian and Norwegian subjects, respectively. Logistic regression analyses revealed FAM46A genotype cc to be an independent predictive factor for non small cell lung cancer risk in the Norwegian subjects after adjustment for age, gender and smoking status. This is the first study to suggest an association between the FAM46A gene VNTR polymorphisms and non small cell lung cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. Logistic regression analyses revealed that genotypes and alleles of BAG6 were independent predictive factor for non small cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, after adjustment for age and gender.

PMID:
25884493
PMCID:
PMC4401550
DOI:
10.1371/journal.pone.0122651
[Indexed for MEDLINE]
Free PMC Article

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