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BMC Cancer. 2015 Mar 8;15:106. doi: 10.1186/s12885-015-1112-5.

Vitamin D and cancer mortality in elderly women.

Wong G1,2,3, Lim WH4,5, Lewis J6,7, Craig JC8,9, Turner R10, Zhu K11,12, Lim EM13, Prince R14,15.

Author information

  • 1Centre for Kidney Research, Children's Hospital at Westmead, Westmead, Australia. germaine.wong@health.nsw.gov.au.
  • 2School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia. germaine.wong@health.nsw.gov.au.
  • 3Centre for Transplant and Renal Research, Westmead Hospital Westmead, Westmead, Australia. germaine.wong@health.nsw.gov.au.
  • 4University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia. Wai.lim@health.wa.gov.au.
  • 5Department of Renal Medicine, Sir Charles Gairdner Hospital, Perth, Australia. Wai.lim@health.wa.gov.au.
  • 6University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia. joshua.lewis@uwa.edu.au.
  • 7Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia. joshua.lewis@uwa.edu.au.
  • 8Centre for Kidney Research, Children's Hospital at Westmead, Westmead, Australia. jonathan.craig@sydney.edu.au.
  • 9School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia. jonathan.craig@sydney.edu.au.
  • 10School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia. r.turner@unsw.edu.au.
  • 11University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia. kathy.zhu@health.wa.gov.au.
  • 12Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia. kathy.zhu@health.wa.gov.au.
  • 13PathWest, Sir Charles Gairdner Hospital, Perth, Australia. eemun.lim@health.wa.gov.au.
  • 14University of Western Australia School of Medicine and Pharmacology, Sir Charles Gairdner Hospital Unit, Perth, Australia. richard.prince@uwa.edu.au.
  • 15Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Perth, Australia. richard.prince@uwa.edu.au.

Abstract

BACKGROUND:

There is increasing evidence that vitamin D deficiency is a risk factor for cancer, however it remains uncertain whether vitamin D deficiency also predisposes to death from cancer. The aim of the study was to determine the association between serum 25-hydroxy-vitamin D (25 (OH) D) concentrations and cancer-specific mortality in a community-based cohort of older post-menopausal women.

METHODS:

Cox proportional regression analyses were conducted to examine the association between serum 25 (OH) D concentrations and the risk of overall and site-specific cancer mortality in a cohort of elderly women.

RESULTS:

Over a median follow-up time of 10 years, a total of 84 cancer deaths were observed. Women with lower serum 25 (OH) D concentrations were at an increased risk of cancer death, but not for incident cancer. The excess risk for cancer death was observed with serum 25 (OH) D concentration less than 64 nmol/L (the median value) [adjusted HR: 1.61 (95% CI: 1.02 - 2.54, p = 0.04]. For every 30 nmol/L reduction in serum 25 (OH) D concentrations, there was a 30% increase in the overall risk of cancer death [adjusted HR: 1.33; 95% CI: 1.03 - 1.72, p = 0.02]. The excess risk appeared to be site-specific and greatest in those with haematological cancers [adjusted HR: 2.13: 95% CI: 1.0 - 4.55, p = 0.05].

CONCLUSIONS:

In elderly women, lower serum 25 (OH) D concentrations appear to be an independent risk factor for cancer-specific mortality, but not a risk factor for the development of cancer.

PMID:
25884436
PMCID:
PMC4356107
DOI:
10.1186/s12885-015-1112-5
[PubMed - indexed for MEDLINE]
Free PMC Article
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