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Nucleic Acids Res. 2015 Jul 1;43(W1):W174-81. doi: 10.1093/nar/gkv342. Epub 2015 Apr 16.

I-TASSER server: new development for protein structure and function predictions.

Author information

1
Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA School of Mathematical Sciences and LPMC, Nankai University, Tianjin, 300071, PR China yangjy@nankai.edu.cn.
2
Department of Computational Medicine and Bioinformatics, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA Department of Biological Chemistry, University of Michigan, 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218, USA zhng@umich.edu.

Abstract

The I-TASSER server (http://zhanglab.ccmb.med.umich.edu/I-TASSER) is an online resource for automated protein structure prediction and structure-based function annotation. In I-TASSER, structural templates are first recognized from the PDB using multiple threading alignment approaches. Full-length structure models are then constructed by iterative fragment assembly simulations. The functional insights are finally derived by matching the predicted structure models with known proteins in the function databases. Although the server has been widely used for various biological and biomedical investigations, numerous comments and suggestions have been reported from the user community. In this article, we summarize recent developments on the I-TASSER server, which were designed to address the requirements from the user community and to increase the accuracy of modeling predictions. Focuses have been made on the introduction of new methods for atomic-level structure refinement, local structure quality estimation and biological function annotations. We expect that these new developments will improve the quality of the I-TASSER server and further facilitate its use by the community for high-resolution structure and function prediction.

PMID:
25883148
PMCID:
PMC4489253
DOI:
10.1093/nar/gkv342
[Indexed for MEDLINE]
Free PMC Article

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