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J Pediatr Gastroenterol Nutr. 2015 Oct;61(4):411-4. doi: 10.1097/MPG.0000000000000823.

Single High-Dose Oral Vitamin D3 Therapy (Stoss): A Solution to Vitamin D Deficiency in Children With Inflammatory Bowel Disease?

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*Department of Gastroenterology, Sydney Children's Hospital †School of Women's and Children's Health, University of New South Wales, Sydney, New South Wales, Australia ‡Department of Pediatrics, University of Otago (Christchurch), Christchurch, New Zealand §Department of Endocrinology, Sydney Children's Hospital, Sydney, New South Wales, Australia ||Department of Paediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel.



Vitamin D deficiency is common in children with inflammatory bowel disease (IBD). The aim of this study was to determine the safety and efficacy of stoss therapy on vitamin D levels during a period of 6 months in children with IBD and vitamin D deficiency (<50 nmol/L).


A retrospective chart review was undertaken, focusing upon children managed in the IBD clinic at Sydney Children's Hospital between 2006 and 2010. Those with a 25-hydroxyvitamin D (25-OHD) level <50 nmol/L and those who received stoss therapy were included in this study.


A total of 76 children received stoss therapy. There was a significant and sustained increase in 25-OHD levels at all of the time points compared with baseline (40.8 ± 7.5 nmol/L), 1 month (145.6 ± 51.8 nmol/L), 3 months (87.1 ± 28.4 nmol/L), and 6 months 69.2 ± 31.3 nmol/L). There were no significant changes in serum calcium, phosphate, or parathyroid hormone at any time points.


Stoss therapy safely and effectively achieved and maintained a level of 25-OHD >50 nmol/L during 6 months in these children with IBD. Further prospective studies are now required to confirm this finding and establish whether this intervention has other benefits.

[Indexed for MEDLINE]

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