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Pediatr Neurol. 2015 May;52(5):544-7. doi: 10.1016/j.pediatrneurol.2015.02.008. Epub 2015 Feb 19.

Pure cannabidiol in the treatment of malignant migrating partial seizures in infancy: a case report.

Author information

1
Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa. Electronic address: dimah-saade@uiowa.edu.
2
Division of Pediatric Neurology, University of Iowa Children's Hospital, Iowa City, Iowa.

Abstract

BACKGROUND:

Malignant migrating partial seizures in infancy is a devastating pharmacoresistent epileptic encephalopathy of unknown etiology characterized by onset in the first 6 months of life, continuous migrating focal seizures with corresponding multifocal electroencephalographic discharges, developmental deterioration, and early mortality. Recent widespread interest in the nonpsychoactive component of the cannabis plant, cannabidiol, as a potential treatment for refractory devastating epilepsies has led to individual trials initiated by families or physicians in states that have legalized medical marijuana with anecdotal success.

PATIENT DESCRIPTION:

We describe a now 10-month-old boy with malignant migrating partial seizures in infancy who made developmental gains and demonstrated sustained seizure reduction with the addition of cannabidiol to his antiepileptic regimen.

CONCLUSION:

This report supports a role for cannabidiol in the treatment of malignant migrating partial seizures in infancy.

KEYWORDS:

CBD; cannabidiol; ketogenic diet; malignant migrating partial epilepsy; migrating partial seizures

[Indexed for MEDLINE]

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