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Nat Rev Drug Discov. 2015 May;14(5):313-28. doi: 10.1038/nrd4554. Epub 2015 Apr 17.

Targeting the sarcomere to correct muscle function.

Author information

1
Division of General Internal Medicine, Department of Medicine, Faculty of Medicine and Dentistry, Clinical Sciences Building, University of Alberta, 11350 83 Avenue, Edmonton, Alberta T6G 2G3, Canada.
2
Department of Biochemistry, Faculty of Medicine and Dentistry, 474 Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.

Abstract

Various human diseases can disrupt the balance between muscle contraction and relaxation. Sarcomeric modulators can be used to readjust this balance either indirectly by intervening in signalling pathways or directly through interaction with the muscle proteins that control contraction. Such agents represent a novel approach to treating any condition in which striated muscle function is compromised, including heart failure, cardiomyopathies, skeletal myopathies and a wide range of neuromuscular conditions. Here, we review agents that modulate the mechanical function of the sarcomere, focusing on emerging compounds that target myosin or the troponin complex.

PMID:
25881969
DOI:
10.1038/nrd4554
[Indexed for MEDLINE]

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