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Int J Biol Macromol. 2015;78:202-8. doi: 10.1016/j.ijbiomac.2015.04.008. Epub 2015 Apr 13.

Runx2: Structure, function, and phosphorylation in osteoblast differentiation.

Author information

1
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India.
2
Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur, Tamil Nadu -603 203, India. Electronic address: selvamurugan.n@ktr.srmuniv.ac.in.

Abstract

Runx2 is a master transcription factor for osteogenesis. The most important phenomenon that makes this protein a master regulator for osteogenesis is its structural integrity. In response to various stimuli, the domains in Runx2 interact with several proteins and regulate a number of cellular events via posttranslational modifications. Hence, in this review we summarized the structural integrity of Runx2 and its posttranslational modifications, especially the phosphorylation responsible for either stimulation or inhibition of its regulatory role in osteogenesis.

KEYWORDS:

Bone; Osteoblast; Phosphorylation; Runx2

PMID:
25881954
DOI:
10.1016/j.ijbiomac.2015.04.008
[Indexed for MEDLINE]

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