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Bioorg Med Chem Lett. 2015;25(10):2096-9. doi: 10.1016/j.bmcl.2015.03.080. Epub 2015 Apr 3.

Cytochalasin derivatives from a jellyfish-derived fungus Phoma sp.

Author information

1
College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
2
College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
3
Department of Food Science and Nutrition, Pukyong National University, Busan 608-737, Republic of Korea.
4
College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea. Electronic address: jhjung@pusan.ac.kr.

Abstract

Four new cytochalasin derivatives (1-4), together with proxiphomin (5), were isolated from a jellyfish-derived fungus Phoma sp. The planar structures and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed moderate cytotoxicity against a small panel of human solid tumor cell lines (A549, KB, and HCT116).

KEYWORDS:

Cytochalasin; Cytotoxicity; Jellyfish-derived fungus; Nemopilema nomurai; Phoma sp.

PMID:
25881821
DOI:
10.1016/j.bmcl.2015.03.080
[Indexed for MEDLINE]

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