Format

Send to

Choose Destination
BMC Vet Res. 2015 Feb 7;11:24. doi: 10.1186/s12917-015-0338-4.

A comparison of pre and post-operative vedaprofen with ketoprofen for pain control in dogs.

Author information

1
Laboratório de Investigação Médica 8, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Av. Doutor Arnaldo, 455, 2° andar, sala 2120, Cerqueira César, 01246-903, São Paulo, SP, Brazil. dfantoni@usp.br.
2
Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. dfantoni@usp.br.
3
Laboratório de Investigação Médica 8, Anestesiologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, Av. Doutor Arnaldo, 455, 2° andar, sala 2120, Cerqueira César, 01246-903, São Paulo, SP, Brazil. keilaida@usp.br.
4
Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. keilaida@gmail.com.
5
Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Brazil, Avenida Prof. Orlando Marques Paiva, 87 Cidade Universitária, 05508-270, São Paulo, SP, Brazil. alinema10@usp.br.

Abstract

BACKGROUND:

This prospective randomized blinded clinical study aimed to investigate the potential of vedaprofen for preventive analgesia, comparing its analgesic effects with ketoprofen administered post-operatively in dogs undergoing maxillectomy or mandibulectomy.

RESULTS:

Pain control was effective and rescue analgesia was not necessary in any group. Pain scores were not significantly different between groups. The respiratory rate and rectal temperature were decreased in all groups at extubation until 6 hours post-extubation compared to baseline. Cortisol and epinephrine levels were increased only at 0.5 hours after extubation in all groups compared to baseline.

CONCLUSIONS:

Vedaprofen did not present any preventive analgesic effect. Pre- and postoperative vedaprofen were as effective as ketoprofen for postoperative pain control.

PMID:
25880775
PMCID:
PMC4324799
DOI:
10.1186/s12917-015-0338-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center