Format

Send to

Choose Destination
BMC Neurol. 2015 Mar 15;15:36. doi: 10.1186/s12883-015-0295-3.

Cohort study ON Neuroimaging, Etiology and Cognitive consequences of Transient neurological attacks (CONNECT): study rationale and protocol.

Author information

1
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. frank.vanrooij@radboudumc.nl.
2
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. anil.tuladhar@radboudumc.nl.
3
Department of Medical Psychology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. roy.kessels@radboudumc.nl.
4
Department of Geriatrics, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. roy.kessels@radboudumc.nl.
5
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognition, Radboud University Nijmegen, 6500 HE, Nijmegen, Netherlands. roy.kessels@radboudumc.nl.
6
Department of Neurology, Rijnstate Hospital, PO Box 9555, 6800 TA, Arnhem, Netherlands. svermeer@rijnstate.nl.
7
Department of Radiology, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. bozena.goraj@radboudumc.nl.
8
Erasmus Medical Center, Department of Neurology, PO Box 2040, 3000 CA, Rotterdam, Netherlands. p.j.koudstaal@erasmusmc.nl.
9
Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HE, Nijmegen, Netherlands. david.norris@donders.ru.nl.
10
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. frankerik.deleeuw@radboudumc.nl.
11
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, Netherlands. ewoud.vandijk@radboudumc.nl.

Abstract

BACKGROUND:

Transient ischemic attacks (TIA) are characterized by acute onset focal neurological symptoms and complete recovery within 24 hours. Attacks of nonfocal symptoms not fulfilling the criteria for TIA but lacking a clear alternative diagnosis are called transient neurological attacks (TNA). Although TIA symptoms are transient in nature, cognitive complaints may persist. In particular, attacks consisting of both focal and nonfocal symptoms (mixed TNA) have been found to be associated with an increased risk of dementia. We aim to study the prevalence, etiology and risk factors of cognitive impairment after TIA or TNA.

METHODS/DESIGN:

CONNECT is a prospective cohort study on cognitive function after TIA and TNA. In total, 150 patients aged ≥45 years with a recent (<7 days after onset) TIA or TNA and no history of stroke or dementia will be included. We will classify events as: TIA, nonfocal TNA, or mixed TNA. Known short lasting paroxysmal neurological disorders like migraine aura, seizures and Ménière disease are excluded from the diagnosis of TNA. Patients will complete a comprehensive neuropsychological assessment and undergo MRI <7 days after the qualifying event and again after six months. The primary clinical outcomes will be cognitive function at baseline and six months after the primary event. Imaging outcomes include the prevalence and evolution of DWI lesions, white matter hyperintensities and lacunes, as well as resting state networks functionality and white matter microstructural integrity. Differences between types of event and DWI, as well as determinants of both clinical and imaging outcomes, will be assessed.

DISCUSSION:

CONNECT can provide insight in the prevalence, etiology and risk factors of cognitive impairment after TIA and TNA and thereby potentially identify a new group of patients at increased risk of cognitive impairment.

PMID:
25880287
PMCID:
PMC4379587
DOI:
10.1186/s12883-015-0295-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center