Format

Send to

Choose Destination
BMJ Case Rep. 2015 Apr 15;2015. pii: bcr2014208960. doi: 10.1136/bcr-2014-208960.

Timing is everything in the treatment of multiple sclerosis.

Author information

1
Department of Clinical Neurosciences, Addenbrooke's Hospital, Cambridge, UK.
2
Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK.
3
Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Abstract

We present two similar cases of relapsing-remitting multiple sclerosis, both of whom received treatment with the monoclonal antibody alemtuzumab, but had significantly different long-term outcomes. Patient A is 12 years into his illness and was treated early in his disease course, he has no disability and continues to perform at a high level as a professional golfer. Patient B was initially started on interferon-β1a therapy and went on to have two disabling relapses on this treatment which resulted in a degree of fixed disability prior to the start of alemtuzumab. 10 years into his disease course he has moderate disability and daily symptoms of spasticity in his legs which impair his quality of life. These two contrasting cases highlight the difficult decision of when to start potent immune modulating therapies for multiple sclerosis in young adults who appear well early in their disease but have the potential to rapidly accrue irreversible disability from future relapses.

PMID:
25878229
PMCID:
PMC4401937
DOI:
10.1136/bcr-2014-208960
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center