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J Virol. 2015 Jul;89(13):6528-31. doi: 10.1128/JVI.00386-15. Epub 2015 Apr 15.

Timing Is Everything: Coordinated Control of Host Shutoff by Influenza A Virus NS1 and PA-X Proteins.

Author information

1
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
2
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada craig.mccormick@dal.ca.

Abstract

Like all viruses, influenza viruses (IAVs) use host translation machinery to decode viral mRNAs. IAVs ensure efficient translation of viral mRNAs through host shutoff, a process whereby viral proteins limit the accumulation of host proteins through subversion of their biogenesis. Despite its small genome, the virus deploys multiple host shutoff mechanisms at different stages of infection, thereby ensuring successful replication while limiting the communication of host antiviral responses. In this Gem, we review recent data on IAV host shutoff proteins, frame the outstanding questions in the field, and propose a temporally coordinated model of IAV host shutoff.

PMID:
25878098
PMCID:
PMC4468473
DOI:
10.1128/JVI.00386-15
[Indexed for MEDLINE]
Free PMC Article

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