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Mult Scler Relat Disord. 2013 Jul;2(3):200-3. doi: 10.1016/j.msard.2012.12.002. Epub 2013 Jan 10.

MRI characteristics of trigeminal nerve involvement in patients with multiple sclerosis.

Author information

1
Department of Neurology, AZ Sint-Jan Hospital, Ruddershove 10, B-8000 Brugge, Belgium. Electronic address: Charlotteswinnen@hotmail.com.
2
Department of Neurology, AZ Sint-Jan Hospital, Ruddershove 10, B-8000 Brugge, Belgium; Department of Neurology, AZ Sint-Blasius Hospital, Kroonveldlaan 50, B-9200 Dendermonde, Belgium.
3
Department of Neurology, AZ Sint-Jan Hospital, Ruddershove 10, B-8000 Brugge, Belgium.
4
Department of Neurology, AZ Sint-Jan Hospital, Ruddershove 10, B-8000 Brugge, Belgium; Department of Radiology and Neuroradiology, AZ Sint-Jan Hospital, Ruddershove 10, B-8000 Brugge, Belgium.

Abstract

BACKGROUND:

Trigeminal neuralgia and central sensory disturbances are common in patients with multiple sclerosis. The anatomic correlation to lesions in the trigeminal nuclei in the brainstem is not well studied.

OBJECTIVE:

We studied the anatomical characteristics of demyelinating lesions of the trigeminal complex in the brainstem on MRI in patients with MS and Clinically Isolated syndrome (CIS).

MATERIALS AND METHODS:

43 Patients with MS or CIS and MRI lesions in the trigeminal complex in the brainstem were selected from a large database of patients referred for MRI because of trigeminal symptoms.

RESULTS AND CONCLUSION:

A linear plaque involving the intrapontine fascicular part of the trigeminal nerve and lesions of the spinal trigeminal nucleus and tract seem to be distinctive MRI findings in patients with RRMS or CIS.

KEYWORDS:

Brainstem; Clinically isolated syndrome (CIS); Demyelination; MRI; Multiple sclerosis; Trigeminal nerve

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