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Mult Scler Relat Disord. 2012 Jul;1(3):123-30. doi: 10.1016/j.msard.2012.03.006. Epub 2012 Apr 7.

B cells in MS: Why, where and how?

Author information

1
Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8.
2
Department of Immunology, University of Toronto, Toronto, Ontario, Canada M5S 1A8. Electronic address: jen.gommerman@utoronto.ca.

Abstract

Multiple sclerosis (MS) is a chronic disease of the central nervous system (CNS), in which auto-aggressive lymphocytes participate in inflammation that causes myelin destruction. Although T lymphocytes have been viewed as important culprits in the inflammatory cascade that results in MS, clinical trial results and animal model data support a role for B lymphocytes in MS pathology. In spite of these encouraging results, the mechanism behind why B cell depletion might be effective for MS treatment remains unknown. Herein we summarize the state of our knowledge for how B cells and their antibody products may influence the initiation and or propagation of MS, drawing from human studies and animal model data.

KEYWORDS:

Antibodies; B cells; EAE; Follicle-like Structures (FLS); MS; Neuroinflammation

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