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Evid Based Complement Alternat Med. 2015;2015:319240. doi: 10.1155/2015/319240. Epub 2015 Mar 22.

Antifungal and antibacterial metabolites from a French poplar type propolis.

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EA 921 SONAS/SFR 4207 QUASAV, Université d'Angers, 16 boulevard Daviers, 49045 Angers Cedex 01, France.
Laboratoire de Bactériologie-Hygiène, Centre Hospitalier Universitaire, 4 rue Larrey, 49933 Angers Cedex 09, France ; Groupe d'Etude des Interactions Hôte Pathogène (GEIHP), Université d'Angers, 4 rue Larrey, 49933 Angers Cedex, France.
Ballot-Flurin Apiculteurs-Abeilles Santé, 75 place Lagardère, 65700 Maubourguet, France.


During this study, the in vitro antifungal and antibacterial activities of different extracts (aqueous and organic) obtained from a French propolis batch were evaluated. Antifungal activity was evaluated by broth microdilution on three pathogenic strains: Candida albicans, C. glabrata, and Aspergillus fumigatus. Antibacterial activity was assayed using agar dilution method on 36 Gram-negative and Gram-positive strains including Staphylococcus aureus. Organic extracts showed a significant antifungal activity against C. albicans and C. glabrata (MIC80 between 16 and 31 µg/mL) but only a weak activity towards A. fumigatus (MIC80 = 250 µg/mL). DCM based extracts exhibited a selective Gram-positive antibacterial activity, especially against S. aureus (SA) and several of its methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains (MIC100 30-97 µg/mL). A new and active derivative of catechin was also identified whereas a synergistic antimicrobial effect was noticed during this study.

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