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Br J Radiol. 2015 Jul;88(1051):20150036. doi: 10.1259/bjr.20150036. Epub 2015 Apr 15.

LungTech, an EORTC Phase II trial of stereotactic body radiotherapy for centrally located lung tumours: a clinical perspective.

Author information

1
1 Department of Radiation Oncology, University Medical Center Freiburg, Freiburg, Germany.
2
2 German Cancer Consortium (DKTK), Heidelberg, Partner Site Freiburg, Germany.
3
3 EORTC Headquarters, Brussels, Belgium.
4
4 Department of Radiation Oncology, Catharina Hospital, Eindhoven, Netherlands.
5
5 Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.
6
6 Institute of Cancer Sciences, Radiotherapy Related Research, The Christie NHS Foundation Trust and University of Manchester, Manchester, UK.
7
7 KU Leuven-University of Leuven, University Hospitals Leuven, Department of Radiation Oncology, Leuven, Belgium.
8
8 Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands.
9
9 Department of Oncology and Radiotherapy, Medical University of Gdańsk, Gdańsk, Poland.
10
10 Department of Radiology, Allgemeines Krankenhaus Celle, Celle, Germany.
11
11 Department of Radiation Oncology, University of Zurich, Zurich, Switzerland.

Abstract

Evidence supports stereotactic body radiotherapy (SBRT) as a curative treatment option for inoperable early stage non-small-cell lung cancer (NSCLC) resulting in high rates of tumour control and low risk of toxicity. However, promising results are mainly derived from SBRT of peripheral pulmonary lesions, whereas SBRT for the central tumours can lead to severe radiation sequelae owing to the spatial proximity to the serial organs at risk. Robust data on the tolerance of mediastinal structures to high-dose hypofractionated radiation are limited; furthermore, there are many open questions regarding the efficiency, safety and response assessment of SBRT in inoperable, centrally located early stage NSCLC, which are addressed in a prospective multicentre study [sponsored by the European Organization for Research and Treatment of Cancer (EORTC 22113-08113-LungTech)]. In this review, we summarize the current status regarding SBRT for centrally located early stage NSCLC that leads to the rationale of the LungTech trial. Outline and some essential features of the study with focus on a summary of current experiences in dose/fraction-toxicity coherences after SBRT to the mediastinal structures that lead to LungTech normal tissue constraints are provided.

PMID:
25873481
PMCID:
PMC4628529
DOI:
10.1259/bjr.20150036
[Indexed for MEDLINE]
Free PMC Article

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