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Expert Rev Vaccines. 2015 Jul;14(7):923-33. doi: 10.1586/14760584.2015.1037289. Epub 2015 Apr 15.

The impact of epidemics of vaccine-preventable disease on vaccine uptake: lessons from the 2011-2012 US pertussis epidemic.

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Seattle Children's Research Institute, Seattle, WA, USA.


Conventional wisdom suggests that if there is a vaccine that is effective in preventing a disease, vaccine uptake will increase when the disease risk is high. Recent evidence, however, suggests that this may not always be the case. In a study we conducted in Washington State, we found no population-level increase in pertussis vaccination of infants during a pertussis epidemic. In this paper, we aim to review what is known about the history of vaccine uptake during epidemics of vaccine-preventable disease, the challenges facing public health campaigns responding to these epidemics, and how the effect of a vaccine-preventable disease epidemic on vaccine uptake can be studied.


epidemics; epidemiological study characteristics; health communication; public health; vaccination

[Indexed for MEDLINE]

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