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Am J Gastroenterol. 2015 May;110(5):646-59; quiz 660. doi: 10.1038/ajg.2015.112. Epub 2015 Apr 14.

ACG Clinical Guideline: Primary Sclerosing Cholangitis.

Author information

1
1] College of Health Solutions, Arizona State University, Phoenix, Arizona, USA [2] Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.
2
Liver Care Network and Organ Care Research, Swedish Medical Center, Seattle, Washington, USA.
3
Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.

Abstract

Primary sclerosing cholangitis is a chronic cholestatic liver disease that can shorten life and may require liver transplantation. The cause is unknown, although it is commonly associated with colitis. There is no approved or proven therapy, although ursodeoxycholic acid is used by many on an empiric basis. Complications including portal hypertension, fat-soluble vitamin deficiency, metabolic bone diseases, and development of cancers of the bile duct or colon can occur.

PMID:
25869391
DOI:
10.1038/ajg.2015.112
[Indexed for MEDLINE]

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